Prologis Eyes 8 MSF San Francisco Mixed-Use

Prologis has submitted plans to redevelop a Caltrain railyard in San Francisco, as reported by the San Francisco Chronicle. At full build-out, the 8 million-square-foot, mixed-use campus would include office, retail and residential space, as well as a new train station.

The entire timeline may span up to two decades, and the proposed neighborhood could be built in multiple stages. In fact, the approval process alone is expected to take two years, according to the same source.

The first phase could include 2.5 million square feet across two high-rise structures and a plaza with retail and restaurants alongside the redeveloped train station. The towers would feature office and residential space.

Prologis owns the 20-acre site, which is bordered by Fourth, King, Seventh, and Townsend streets. However, Caltrain holds an easement to operate on the land, which serves as its northern terminus and active maintenance yard. Downtown San Francisco is about 2 miles away.

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The idea of redeveloping the Golden City’s railyards emerged more than a decade ago with a proposal from late mayor Ed Lee. Yet, the ambitious $8.3 billion project dubbed the Portal has not yet been funded, according to the Chronicle.

Speaking of redevelopment, Prologis is no stranger to such endeavors, though the projects are typically within the industrial sector. About 3 miles from its latest railyard proposal, the company seeks to replace four warehouses built in the 1940s with a 1.6 million-square-foot, multi-story industrial park.

Prologis’ development pipeline made up 3.1 percent of its total $98.7 billion portfolio in December 2025, according to the firm’s latest quarterly report. Those projects accounted for more than $3 billion, up 6.7 percent year-over-year.

Notable companies reshaping San Francisco’s skyline

Another one of the largest commercial real estate companies spearheading San Francisco redevelopment is Fifth Space, formerly Associate Capital, which leads the Potrero Power Station project. Construction is underway on the mixed-use development that replaces a century-old plant with 1.6 million square feet of office space and 2,600 residential units.

In the same neighborhood as Potrero Point, Brookfield Properties is also redeveloping Pier 70, a former industrial site, into a mixed-use destination encompassing approximately 2 million square feet of commercial space and 2,000 residential units. Earlier this year, General Catalyst, a venture capital firm, signed a lease for 70,000 square feet at the development’s Building 12.