Durham, NC Commercial Real Estate for Lease
Search 240 commercial real estate listing(s) for lease in Durham, NC, including the latest local availabilities across all property types and find helpful local stats in the Market Overview section below.
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Patterson Road NC, Falls Lake, Durham, NC
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400 West Main Street, Warehouse District, Durham, NC
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1415 NC 54 Durham, Parkwood, Durham, NCSpace Type
- Office
For Lease- $17.00 - $21.00/SF/YR
4 spaces available / 983 - 2,074 SF -
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Looking for more specific results? Choose your preferred property type

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University Dr & Shannon Rd, Valley Run, Durham, NC
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4170 Sancar Way, Research Triangle Park, Durham, NC
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2710 Weck Drive, Taylor Estates, Durham, NC
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4336 N Roxboro St, Old Farm, Durham, NC
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4201 North Roxboro Street, Scarsdale Village, Durham, NCSpace Type
- Retail
For Lease- $30.00/SF/YR
1 space available / 1,221 SF -
4102 South Miami Blvd, Research Triangle Park, Durham, NC
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1620 Guess Rd, West Murray - Broad, Durham, NC
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NC-55 & Old Powell Rd, Wynterfield, Durham, NC
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6015 & 6011 Fayetteville Rd, Crooked Creek, Durham, NCSpace Type
- Office
For Lease- $1,066.67/MO
1 space available / 800 SF -
224 North Hoover Road, Merrick Moore, Durham, NC
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1910 Sedwick Rd, Audubon Park, Durham, NCSpace Type
- Office
For Lease- $1,500.00 - $1,650.00/MO
3 spaces available / 1,030 - 1,100 SF -
Guess Road and Latta Road, Lochaven Hills, Durham, NC
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3300 & 3204 North Duke Street, Stadium Heights, Durham, NC
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112 S Duke St, Downtown Durham, Durham, NC
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800 Park Offices Drive 1st floor, Durham, NC
Frontier RTP - Research Triangle Park
Frontier RTPSpace Type- Private Offices
For Lease-
From $450/month
Space for 1 to 150 people -
4220 NC Hwy 55, Copper Creek, Durham, NCSpace Type
- Office
For Lease- $22.00/SF/YR
1 space available / 2,860 SF -
4130 Sancar Way, Research Triangle Park, NC
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1065 Yunus Road, Wynterfield, Durham, NC
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121 Hunt St., Old North Durham, Durham, NC
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1716 Camden Ave, Colonial Village, Durham, NC
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3375 Hopson Road, Audubon Park, Durham, NC
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3209 Guess Rd, Omah Street, Durham, NCSpace Type
- Office
For Lease- $21.00/SF/YR
2 spaces available / 620 SF -
15 TW Alexander Drive, Durham, NC
North Carolina Biotechnology Center
North Carolina Biotechnology Center -
5826 Fayetteville Road, Folkestone, Durham, NCSpace Type
- Office
For Lease- $25.00/SF/YR
4 spaces available / 237 - 1,052 SF -
7072 NC Hwy 751, The Landing at Southpoint, Durham, NCSpace Type
- Office
For Lease- $25.00/SF/YR
1 space available / 3,600 SF -
6320-6350 Quadrangle Drive, The Landing at Southpoint, Chapel Hill, NCSpace Type- Office
For Lease Contact for pricing -
4018 Patriot Drive, Research Triangle Park, Durham, NC
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621 Broad Street, Old West Durham, Durham, NC