Durham, NC Commercial Real Estate for Lease
Search 242 commercial real estate listing(s) for lease in Durham, NC, including the latest local availabilities across all property types and find helpful local stats in the Market Overview section below.
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4201 North Roxboro Street, Scarsdale Village, Durham, NCSpace Type
- Retail
For Lease- $30.00/SF/YR
1 space available / 1,221 SF -
4220 NC Hwy 55, Copper Creek, Durham, NCSpace Type
- Office
For Lease- $22.00/SF/YR
1 space available / 2,860 SF -
3300 & 3204 North Duke Street, Stadium Heights, Durham, NC
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5704 Fayetteville Road, Folkestone, Durham, NCSpace Type- Office
For Lease Contact for pricing -
Looking for more specific results? Choose your preferred property type

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Lynn Road & Holloway Street, Amberlynn Valley, Durham, NC
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121 Hunt St., Old North Durham, Durham, NC
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2525 Whilden Dr, Wynterfield, Durham, NC
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3116 Duke Street, Stadium Heights, Durham, NCSpace Type- Office
For Lease Contact for pricing -
5409-5475 Lumley Rd, Ashley Forest, Durham, NCSpace Type
- Office
For Lease- $19.00 - $22.00/SF/YR
5 spaces available / 900 - 2,450 SF -
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9 Laboratory Drive #263, Durham, NC
Alexandria LaunchLabs - Alexandria Center for Agtech
Alexandria LaunchLabs -
1951 TW Alexander Drive, Stirrup Creek, Durham, NC
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5 National Wy, Research Triangle Park, Durham, NC
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810 Ramseur Street, Edgemont, Durham, NCSpace Type- Other
For Lease Contact for pricing -
4528 Hillsborough Rd, West Hills, Durham, NCSpace Type
- Office
For Lease- $20.00/SF/YR
1 space available / 750 SF -
4170 Sancar Way, Research Triangle Park, Durham, NC
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5 National Way, Research Triangle Park, Durham, NC
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15 TW Alexander Drive, Durham, NC
North Carolina Biotechnology Center
North Carolina Biotechnology Center -
800 Park Offices Drive 1st floor, Durham, NC
Frontier RTP - Research Triangle Park
Frontier RTPSpace Type- Private Offices
For Lease-
From $450/month
Space for 1 to 150 people -
4900 Prospectus Drive, Research Triangle Park, Durham, NC
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1910 Sedwick Rd, Audubon Park, Durham, NCSpace Type
- Office
For Lease- $1,500.00 - $1,650.00/MO
3 spaces available / 1,030 - 1,100 SF -
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3415 Hillsborough Road, Old West Durham, Durham, NC
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857 South Briggs Avenue, North Carolina Central University, Durham, NC
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4001 North Carolina 54, Research Triangle Park, Morrisville, NC
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3375 Hopson Road, Audubon Park, Durham, NC
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4018 Patriot Drive, Research Triangle Park, Durham, NC
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5116 North Roxboro Street, Old Farm, Durham, NC
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4000 Sancar Way, Research Triangle Park, Durham, NCSpace Type
- Office
For Lease- $28.50/SF/YR
8 spaces available / 1,332 - 5,471 SF -
Research Triangle Park #220, Durham, NC
Alexandria LaunchLabs - Alexandria Center for Advanced Technologies
Alexandria LaunchLabs -
3400 Croasdaile Dr, Croasdaile, Durham, NCSpace Type
- Office
For Lease- $25.00/SF/YR
1 space available / 3,574 SF -
2320 Ferrell Road, Stillwood, Durham, NC