324 W. 125th Street

For Lease

324 W. 125th Street, New York, NY 10035

The total number of office spaces available at 324 W. 125th Street is 1. Leasing opportunities in the building include office. There is a total of 6,780 square feet of space currently available for rent at this address. Of this, the minimum divisible area is 6,780 square feet.

Space Available For Lease 1

Contacts

Michael G. Murphy

Douglas Elliman Commercial - Long Island

Property Details

  • Property Type Office - General Office
  • Property Size 6,780 SF
  • Units 1
  • Building Class A
  • Date Updated Apr 27, 2026
Discover the vibrant energy and endless opportunities surrounding the location in New York City. Situated in the heart of East Harlem, the area is teeming with historic charm, diverse culture, and convenient amenities. Within walking distance, find renowned dining options, including Red Rooster and Sylvia's Restaurant, perfect for business lunches or after-work gatherings. The property also offers proximity to notable attractions such as the Museum of the City of New York and the picturesque Marcus Garvey Park, providing a perfect balance of work and leisure. Embrace the dynamic mix of commerce and culture in this bustling neighborhood.This ±6,780 SF second‑floor suite sits on a highly visible corner along East 125th Street directly above CVS, offering strong street presence and elevator access. The space had previously operated as a restaurant and was fully zoned for medical use when the building was taken over. No imaging equipment remains, allowing a new operator to design and install systems tailored to their specialty. With a properly managed radiology practice capable of handling an estimated 275 to 375 patients per day, the location offers significant potential for high‑volume outpatient services. The office is supported by a 3000A, 120/208 volt, 3‑phase, 4‑wire underground electrical service, suitable for imaging, diagnostics, and other power‑intensive medical uses. This sublease presents a rare opportunity for any medical, dental, or professional practice seeking to expand its presence in an under‑served uptown community. The location provides immediate access to a dense patient base and allows full control over clinical expansion and outpatient footprint. With twelve years remaining on a twenty‑year master lease, the space offers long‑term stability along with a flexible lease structure and favorable terms. Ownership is motivated and open to negotiation for the right tenant. The surrounding area is anchored by national retailers, community services, and major transit options, including nearby express trains, creating exceptional visibility, accessibility, and patient convenience. This turnkey suite is ideal for a practice looking to grow, strengthen its outpatient operations, or establish a flagship uptown location in a vibrant, high‑traffic corridor.
Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

Highlights

  • ±6,780 SF second-floor medical/professional suite with prominent East 125th Street corner exposure and elevator access
  • Fully zoned medical space supported by a 3000A, 120/208V, 3-phase electrical service suitable for imaging and high-intensity clinical operations
  • Highly accessible location near express trains and major transit corridors, offering exceptional visibility and connectivity for patients and staff
  • Long-term stability with twelve years remaining on a twenty-year master lease and ownership willing to structure favorable sublease terms
  • Strong outpatient demand in an under-served uptown market, with radiology throughput potential estimated at 275–375 patients per day

Attachments

Getting around

  • 99/100

    Walk Score ®

  • 100/100

    Transit Score ®

  • 80/100

    Bike Score ®

Powered by Walk Score ®

Location

  • City New York, NY
  • Neighborhood Harlem
  • Zip Code 10035
  • Market Manhattan

Points of Interest

  • Lenox Avenue & 125th Street at Southwest Corner

    0.39 miles

  • Lenox Avenue & 125th Street at Northwest Corner

    0.39 miles

  • Lenox Avenue & 125th Street at Southeast Corner

    0.41 miles

  • Lenox Avenue & 125th Street at Northeast Corner

    0.41 miles

  • Lenox Avenue & 116th Street at Northwest Corner

    0.58 miles

  • Lenox Avenue & 116th Street at Northeast Corner

    0.59 miles

  • Lenox Avenue & 116th Street at Southwest Corner

    0.60 miles

  • Lenox Avenue & 116th Street at Southeast Corner

    0.61 miles

  • Lenox Avenue & 135th Street at Southwest Corner

    0.64 miles

  • Lenox Avenue & 135th Street at Southeast Corner

    0.65 miles

  • Shell

    0.10 miles

  • Mobil

    1.04 miles

  • BP

    1.10 miles

  • FLO

    2.07 miles

  • ChargePoint

    2.11 miles

  • plugNYC

    2.44 miles

  • Tesla Supercharger

    2.52 miles

  • Hamilton Grange

    0.82 miles

  • Harlem River South Lot

    1.46 miles

  • 153rd Street South Lot

    1.48 miles

  • Edison ParkFast

    1.49 miles

  • Harlem River Lot

    1.49 miles

  • 153rd Street North Lot

    1.51 miles

  • Mount Sinai

    1.52 miles

  • East River Plaza Garage

    1.52 miles

  • Harlem River North Lot

    1.55 miles

  • MPG

    1.55 miles

  • Aloft Hotel

    0.10 miles

  • Apollo Hotel

    0.30 miles

  • La Maison d'Art Private Gallery

    0.39 miles

  • L-Hostels

    0.43 miles

  • Efuru Guest House

    0.44 miles

  • Park View Hotel

    0.84 miles

  • Astor on the Park

    0.92 miles

  • Lotus Accomodation

    0.95 miles

  • Jazz on the Park

    0.96 miles

  • Hotel

    1.08 miles

  • Lincoln Market

    0.17 miles

  • Key Food

    0.17 miles

  • Foodtown

    0.29 miles

  • Lidl

    0.32 miles

  • Apple Tree Supermarket

    0.35 miles

  • Burlington

    0.36 miles

  • Foodtown of Frederick Douglas Blvd

    0.36 miles

  • Whole Foods Market

    0.38 miles

  • Marshalls

    0.38 miles

  • C-Town

    0.41 miles

324 W. 125th Street Listing Brief

  • Leasing rates here can depend on a variety of factors, including the quality rating of the property (property class or building class), the position of the available space within the building, any unique attributes that the listed space may include, as well as on the availability of on-site or nearby amenities. Reach out using the contact form available on this page to schedule a tour or to get more detailed information on the most modern facilities and amenities that 324 W. 125th Street has to offer.

  • See the listing area details for information and ratings regarding the degree of walkability in the neighborhood, the accessibility and frequency of public transit options, as well as the level of availability and quality of biking infrastructure in the area. What’s more, you can use the interactive map for a good overview of the area. Location details also include a breakdown of distance from the property to several essential amenities and points of interest, which may include parking facilities, fuel stations, stores, or hotels.

  • This property is in the Harlem neighborhood of New York and located within zip code 10035.

    324 W. 125th Street is rated class A. The building includes 6,780 square feet, of which 6,780 square feet is rentable office space.

Contact Listing Broker
Michael G. Murphy

Douglas Elliman Commercial - Long Island

  1. 1Main information
  2. 2Extra information
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.