4321 Medical Park Dr

For Lease

4321 Medical Park Dr, Durham, NC 27704

The total number of office spaces available at 4321 Medical Park Dr is 4. Leasing opportunities in the building include office. There is a total of 24,200 square feet of space currently available for rent at this address. Of this, the minimum divisible area is 3,800 square feet.

Space Available For Lease 4

Contacts

broker
Brian Farmer

Lee & Associates

Property Details

  • Property Type Office - General Office
  • Property Size 79,440 SF
  • Lot Size 8.17 Acre
  • Building Class A
  • Year Built 2001
  • Date Updated Aug 19, 2025
4321 Medical Park Drive is a Class A office building located in a large medical hub, Independence Park, across from Duke Regional Hospital in North Durham. The thriving park contains various medical and health-related occupants as well as retail and restaurants nearby. Downtown Durham and Duke University are only 4 and 5 miles away respectively.Class A office space for lease in North Durham available December 1, 2025. Ability to combine suites for up to 27,735 SF.
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Highlights

  • 79,202 SF two-story medical and office building
  • Ability to combine suites for up to 27,735 SF
  • Built in 2001 - attractive concrete, steel and glass construction
  • Dock loading in rear of building
  • Freight elevator and backup generator onsite
  • Gorgeous atrium with circular staircase
  • High ceilings and upgraded finishes
  • Lease rate: $23.00/SF full service
  • Plentiful parking onsite (4.8 per 1,000 SF)

Getting around

  • 20/100

    Walk Score ®

  • 30/100

    Transit Score ®

  • 30/100

    Bike Score ®

Powered by Walk Score ®

Location

  • City Durham, NC
  • Neighborhood Summer Meadow
  • Zip Code 27704
  • Market Raleigh Durham

Points of Interest

  • Durham

    3.63 miles

  • Shell

    0.71 miles

  • Sheetz

    0.76 miles

  • Bragtown Shell

    0.87 miles

  • Citgo

    0.88 miles

  • Kangaroo Express

    0.89 miles

  • Family Fare

    1.27 miles

  • Harris Teeter Fuel

    1.67 miles

  • Costco Gasoline

    1.86 miles

  • Town 'N' Country

    1.97 miles

  • EVgo

    9.53 miles

  • Saint Lukes Episcopal Church

    2.91 miles

  • Biddle Music Parking Lot

    3.00 miles

  • Branson Hall Parking

    3.01 miles

  • Brown Parking Lot

    3.03 miles

  • Bivins Parking Lot

    3.05 miles

  • Pegram Parking Lot

    3.08 miles

  • Wilson House/Red Zone

    3.12 miles

  • Epworth Parking Lot

    3.14 miles

  • Randolph Parking Lot

    3.18 miles

  • Gilbert-Addoms Lot

    3.22 miles

  • Red Roof Inn Durham Duke University Medical Center

    2.14 miles

  • Holiday Inn Express

    2.23 miles

  • Hampton Inn & Suites North I 85

    2.23 miles

  • Super 8 by Wyndham Durham/University Area NC

    2.28 miles

  • Carolina Duke Inn

    2.33 miles

  • Comfort Inn Medical Park

    2.68 miles

  • Courtyard

    2.80 miles

  • Duke Tower

    3.10 miles

  • Hilton Garden Inn Durham/University Medical Center

    3.37 miles

  • Residence Inn Durham McPherson/Duke University Medical Center Area

    3.41 miles

  • Roses

    0.64 miles

  • Burlington

    0.71 miles

  • Food Lion

    0.88 miles

  • Harris Teeter

    1.58 miles

  • Ross

    2.00 miles

  • Red White Grocery

    2.02 miles

  • Cross Creek Shopping Center

    2.05 miles

  • Willowdale Shopping Center

    2.17 miles

  • Northgate Shopping Mall

    2.26 miles

  • Loehmann's Plaza

    2.70 miles

4321 Medical Park Dr Listing Brief

  • Leasing rates here can depend on a variety of factors, including the quality rating of the property (property class or building class), the position of the available space within the building, any unique attributes that the listed space may include, as well as on the availability of on-site or nearby amenities. Reach out using the contact form available on this page to schedule a tour or to get more detailed information on the most modern facilities and amenities that 4321 Medical Park Dr has to offer.

  • See the listing area details for information and ratings regarding the degree of walkability in the neighborhood, the accessibility and frequency of public transit options, as well as the level of availability and quality of biking infrastructure in the area. What’s more, you can use the interactive map for a good overview of the area. Location details also include a breakdown of distance from the property to several essential amenities and points of interest, which may include parking facilities, fuel stations, stores, or hotels.

  • This property is in the Summer Meadow neighborhood of Durham and located within zip code 27704.

    4321 Medical Park Dr was originally completed in 2001 and is rated class A. The building includes 79,440 square feet, of which 24,200 square feet is rentable office space.

In-Depth Research Available for this Property

Access more in-depth information about this property — including ownership, tenant details, property characteristics and transaction history, along with local market insights and much more — on CommercialEdge.

Contact Listing Broker
broker
Brian Farmer

Lee & Associates

  1. 1Main information
  2. 2Extra information
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