221 Independence St

For Lease

221 Independence St, Cape Girardeau, MO 63703

You can currently find 1 retail space(s) available for lease at 221 Independence St. Designated use type for space listed here includes street retail. Current retail listings at this property total 1,450 square feet. Lease type options include Full Service. Expand the listing and property details below for additional information on leasing opportunities at 221 Independence St.

Space Available For Lease 1

Contacts

Chris Cole, JD, CCIM, ALC

Lorimont Commercial Real Estate

Property Details

  • Property Type Retail - Street Retail
  • Property Size 1,450 SF
  • Units 1
  • Lot Size 0.32 Acre
  • Year Built 1940
  • Date Updated Aug 3, 2026
Downtown Cape Girardeau location less than a block from Spanish St. and 1.5 blocks from Main St.1,450 SF retail boutique space available for lease in Downtown Cape Girardeau! Retail showroom with public restroom, three changing/fitting rooms, and storage space. Lots of natural light and huge windows. Make this space your next retail boutique home for just $1,500 per month!
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Reach out to the broker for more info on lease terms and amenities

Highlights

  • $1,500 per month!
  • 1,450 SF retail space
  • High traffic
  • Large windows
  • Perfect for boutique shop

Getting around

  • 68/100

    Walk Score ®

  • 57/100

    Bike Score ®

Powered by Walk Score ®

Location

  • City Cape Girardeau, MO
  • Zip Code 63703

Points of Interest

  • Gordonville

    9.15 miles

  • Jackson

    9.53 miles

  • Iron Moountain Junction

    9.81 miles

  • Kidd's gas station

    1.82 miles

  • Rhodes

    2.99 miles

  • Mobil

    3.45 miles

  • Rhodes Travel Center

    4.93 miles

  • Over the road truck parking

    4.86 miles

  • Church overflow parking

    5.72 miles

  • Port Cape Girardeau Restaurant and Lounge

    0.16 miles

  • Kenny's Flippin Burgers

    0.25 miles

  • McDonald's

    1.54 miles

  • Hardee's

    1.60 miles

  • Arby's

    1.70 miles

  • Fazoli's

    1.77 miles

  • Wendy's

    1.79 miles

  • Long John Silver's

    1.80 miles

  • Watami Sushi & Hibachi Steakhouse

    1.80 miles

  • Captain D's

    1.81 miles

  • Walmart Neighborhood Market

    1.61 miles

  • ALDI

    1.67 miles

  • Schnucks

    1.87 miles

  • Kmart

    1.87 miles

  • West Park Mall

    2.79 miles

  • TJ Maxx

    3.25 miles

  • Target

    3.29 miles

  • Walmart Supercenter

    3.61 miles

  • Kohl's

    3.62 miles

  • Bob's Food Liner

    6.10 miles

221 Independence St Listing Brief

  • A property’s location contributes to the asking rent almost as much as its characteristics do. For instance, central urban locations with high walkability or suburban locations with ample parking and easy access by car will claim higher rents but offer superior access to your customer base. Likewise, the quality of the building systems and property finishes have a significant impact on how businesses can conduct their activity there, as well as on the experience of their customers.

    Retail space at 221 Independence St asks $1,500.00/MO per square foot.

  • The property includes 1,450 square feet of retail space for lease. Of this total, 1,450 square feet are Street Retail.

    Lease agreement conditions for the availability at this property include Full Service.

    For more information or to schedule a tour of the property, use the convenient contact form on this page to get in touch with a representative.

  • You should keep in mind that different areas gradually build a reputation as hotspots or desirable corridors for shopping, eating, or other entertainment and consumer activities. So, while renting retail space in an area with a well-established high-end reputation might mean more customers that are more willing to spend, it will also place you in a more competitive environment.

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