Map of Property

221 N Main St

For Lease

221 N Main St, Natick, MA 01760

The total number of office spaces available at 221 N Main St is 2. Leasing opportunities in the building include office. There is a total of 3,400 square feet of space currently available for rent at this address. Of this, the minimum divisible area is 1,200 square feet.

Space Available For Lease 2

Contacts

Craig S. Johnston

R.W. Holmes

Dean Blackey

R.W. Holmes

Property Details

  • Property Type Office
  • Property Size 28,465 SF
  • Date Updated May 11, 2026

220 North Main Street in Natick offers renovated, flexible office space in a highly visible location on Route 27/9, with direct access to Natick Mall, Route 9, and major regional highways.
The three-story, locally owned and managed building features modern upgrades, on-site showers, ample parking, and walkable amenities—an efficient suburban office option for businesses seeking convenience, access, and a professional setting.

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Getting around

  • 73/100

    Walk Score ®

Powered by Walk Score ®

Location

  • City Natick, MA
  • Neighborhood Natick
  • Zip Code 01760
  • Market Worcester Springfield

Points of Interest

  • Natick Center

    1.23 miles

  • West Natick

    2.10 miles

  • Framingham

    3.58 miles

  • Wellesley Hills

    4.24 miles

  • Wellesley Farms

    4.65 miles

  • Needham Heights

    6.31 miles

  • Eliot

    7.39 miles

  • Hersey

    7.55 miles

  • Waltham

    8.08 miles

  • Southborough

    8.82 miles

  • Autel

    0.77 miles

  • Gulf

    0.78 miles

  • Sunoco

    1.08 miles

  • Speedway

    1.20 miles

  • Cumberland Farms

    1.35 miles

  • Mobil

    1.40 miles

  • Mabardy's Gulf

    1.45 miles

  • Shell

    1.74 miles

  • Tesla Supercharger

    1.81 miles

  • ChargePoint

    5.70 miles

  • MathWorks Apple Hill West Garage

    0.32 miles

  • MathWorks Apple Hill East Garage

    0.49 miles

  • Car Parking

    0.76 miles

  • Truck Parking

    0.76 miles

  • Lakeside Parking Garage

    0.89 miles

  • Cochituate North Lot

    1.15 miles

  • Parking Deck C

    1.18 miles

  • Parking Deck D

    1.22 miles

  • Parking Deck E

    1.28 miles

  • Premium Parking Deck B

    1.28 miles

  • Hampton Inn

    0.96 miles

  • Residence Inn

    1.03 miles

  • Courtyard Boston Natick

    1.30 miles

  • Red Roof Inn

    1.48 miles

  • Travelodge

    1.49 miles

  • The Verve

    1.55 miles

  • Monticello Inn Framingham

    1.96 miles

  • Econo Lodge

    4.44 miles

  • Hotel Indigo - Newton Riverside

    5.80 miles

  • Boston Marriott Newton

    6.00 miles

  • Stop & Shop

    0.06 miles

  • Burlington

    1.08 miles

  • ALDI

    1.10 miles

  • Donelan's

    1.11 miles

  • Nordstrom

    1.21 miles

  • Shopper's Find

    1.26 miles

  • Natick Mall

    1.27 miles

  • Macy's

    1.44 miles

  • Roche Bros.

    1.67 miles

  • TJ Maxx

    1.77 miles

221 N Main St Listing Brief

  • Leasing rates here can depend on a variety of factors, including the quality rating of the property (property class or building class), the position of the available space within the building, any unique attributes that the listed space may include, as well as on the availability of on-site or nearby amenities. Reach out using the contact form available on this page to schedule a tour or to get more detailed information on the most modern facilities and amenities that 221 N Main St has to offer.

  • See the listing area details for information and ratings regarding the degree of walkability in the neighborhood, the accessibility and frequency of public transit options, as well as the level of availability and quality of biking infrastructure in the area. What’s more, you can use the interactive map for a good overview of the area. Location details also include a breakdown of distance from the property to several essential amenities and points of interest, which may include parking facilities, fuel stations, stores, or hotels.

  • This property is in the Natick neighborhood of Natick and located within zip code 01760.

    The building includes 28,465 square feet, of which 3,400 square feet is rentable office space.

Contact 221 N Main St
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