Map of Property

The American Twine Building - Sublease

For Lease

222 Third Street, Cambridge, MA 02142

The total number of office spaces available at The American Twine Building - Sublease is 1. Leasing opportunities in the building include general office. There is a total of 1,691 square feet of space currently available for rent at this address. Of this, the minimum divisible area is 1,691 square feet.

Space Available For Lease 1

Contacts

Owen Murphy

Boston Realty Advisors

Property Details

  • Property Type Office - General Office
  • Property Size 120,668 SF
  • Building Class B
  • Date Updated Jul 7, 2026
The American Twine Building in the heart of Cambridge, MA. This vibrant area is home to prestigious universities, including the renowned Massachusetts Institute of Technology, and an array of tech companies, creating a hub of innovation and collaboration. Enjoy convenient access to the serene Charles River for moments of relaxation, while nearby restaurants and cafes offer an array of culinary delights. Experience the rich cultural scene with world-class museums and theaters just a short distance away. The location provides an inspiring environment for Office / Office Building tenants, with its blend of academic, technological, and cultural influences.Located in the heart of East Cambridge’s Kendall Square submarket, the American Twine Building is a historic brick and beam office building just a short walk from the Kendall Square Red Line and Lechmere Green Line MBTA stations, surrounded by new restaurant and retail offerings. Originally an industrial property, the approximately 122,000 SF building sits on a nearly two-acre site, placing tenants steps from world-class universities and a thriving ecosystem of biotech and technology companies, with close proximity to both MIT and Harvard providing access to a deep pool of elite talent. This ±1,691 SF suite offers the building’s signature character, exposed brick and beams with large windows that allow an abundance of natural light throughout. The space is ideally suited for a growing technology, professional services, or life science administrative user seeking a creative office environment with built-in flexibility and a defined term
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Attachments

Getting around

  • 97/100

    Walk Score ®

  • 88/100

    Transit Score ®

  • 98/100

    Bike Score ®

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Location

  • City Cambridge, MA
  • Neighborhood East Cambridge
  • Zip Code 02142
  • Market Boston

Points of Interest

  • Kendall/MIT

    0.40 miles

  • Union Square

    0.96 miles

  • North Station

    1.10 miles

  • Central

    1.17 miles

  • Park Street

    1.19 miles

  • Green Line (Inbound) | Red Line (All Trains)

    1.21 miles

  • Sullivan Square

    1.22 miles

  • Boylston

    1.27 miles

  • Downtown Crossing

    1.31 miles

  • Hynes

    1.38 miles

  • Tesla Supercharger

    0.21 miles

  • Shell

    0.45 miles

  • ChargePoint

    0.91 miles

  • JuiceBar

    0.92 miles

  • Speedway

    1.01 miles

  • Tesla Destination Charger

    1.22 miles

  • Pearl Street Auto Sales

    1.45 miles

  • Gulf

    1.59 miles

  • Sunoco

    1.69 miles

  • First Street Garage

    0.20 miles

  • 84 Athenaeum St Garage

    0.23 miles

  • Kendall Square Garage

    0.25 miles

  • Kendall Square Parking

    0.25 miles

  • One Memorial Garage

    0.36 miles

  • Museum of Science Parking Garage

    0.44 miles

  • One Kendall Square Garage

    0.45 miles

  • Cambridge Center Garage

    0.46 miles

  • Ford Lot

    0.48 miles

  • E51 Lot

    0.48 miles

  • Hotel Marlowe

    0.30 miles

  • The Royal Sonesta Boston

    0.30 miles

  • Boston Marriott Cambridge

    0.39 miles

  • Hampton Inn Boston/Cambridge

    0.39 miles

  • Fairfield Inn and Suites

    0.41 miles

  • Residence Inn Cambridge

    0.43 miles

  • Holiday Inn Express Hotel & Suites

    0.44 miles

  • The Kendall Hotel

    0.46 miles

  • The Liberty Hotel

    0.64 miles

  • John Jeffries House

    0.66 miles

  • Cambridgeside

    0.27 miles

  • Brothers Marketplace

    0.34 miles

  • Star Market

    0.51 miles

  • Marshalls

    0.57 miles

  • Target

    0.82 miles

  • Whole Foods Market

    0.87 miles

  • DeLuca's Market

    0.93 miles

  • getir: groceries in minutes

    0.94 miles

  • Vinal General Store

    0.94 miles

  • Cleenland

    1.01 miles

222 Third Street Listing Brief

  • Leasing rates here can depend on a variety of factors, including the quality rating of the property (property class or building class), the position of the available space within the building, any unique attributes that the listed space may include, as well as on the availability of on-site or nearby amenities. Reach out using the contact form available on this page to schedule a tour or to get more detailed information on the most modern facilities and amenities that 222 Third Street has to offer.

  • See the listing area details for information and ratings regarding the degree of walkability in the neighborhood, the accessibility and frequency of public transit options, as well as the level of availability and quality of biking infrastructure in the area. What’s more, you can use the interactive map for a good overview of the area. Location details also include a breakdown of distance from the property to several essential amenities and points of interest, which may include parking facilities, fuel stations, stores, or hotels.

  • This property is in the East Cambridge neighborhood of Cambridge and located within zip code 02142.

    222 Third Street is rated class B. The building includes 120,668 square feet, of which 1,691 square feet is rentable office space.

Contact Listing Broker
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