300 Massachusetts Avenue

For Lease

300 Massachusetts Avenue, Cambridge, MA 02139

There are currently 6 spaces available at this property. This building incorporates a total of 245,937 square feet. Of that, 213,092 square feet is rentable space. The general use of the property is designated as unassigned. Units available for lease at 300 Massachusetts Avenue include spaces that are described as unassigned.
Current availabilities are located on multiple floors in the building. The largest available space at this property is 35,517 square feet. Listed spaces in this building start at a size of 35,515 square feet. Listings at 300 Massachusetts Avenue are available starting 10 Feb, 2026.
See more information under each individual listing below for additional details, such as divisible space, renewal options, lease type, possibility of sublease and more.

Space Available For Lease 6

Contacts

Julia Ryan

Cushman & Wakefield

Connor T. Barnes

Cushman & Wakefield

Property Details

  • Property Type Unassigned
  • Property Size 245,937 SF
  • # of Floors 6
  • Parking Ratio 1.00 / 1,000 SF
  • Year Built 2016
  • Date Updated Jun 12, 2026
Now fully permitted, 300 Mass Ave is moving into the construction phase, with completion and occupancy anticipated in early 2016. The research and office portions of the building – all but 15,000 square feet that has been designated for retail uses – will be occupied by Millennium/Takeda, a life science company that is currently in University Park at MIT and will be expanding its footprint to support a more extensive research program. Retail shops and restaurants will occupy nearly the entire frontage of the building along Massachusetts Avenue, and will be identified when construction of the project is further along.
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Getting around

  • 97/100

    Walk Score ®

  • 68/100

    Transit Score ®

  • 99/100

    Bike Score ®

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Location

  • City Cambridge, MA
  • Neighborhood Cambridgeport
  • Zip Code 02139
  • Market Boston

Points of Interest

  • Central

    0.32 miles

  • Kendall/MIT

    0.68 miles

  • Kenmore

    0.93 miles

  • Lansdowne

    1.02 miles

  • Union Square

    1.06 miles

  • Hynes

    1.13 miles

  • Saint Mary's Street

    1.20 miles

  • Harvard Square

    1.28 miles

  • Church Street - Johnston Gate

    1.32 miles

  • Church Street - West

    1.32 miles

  • ChargePoint

    0.42 miles

  • Speedway

    0.72 miles

  • Shell

    0.80 miles

  • Magazine Beach Shell

    0.87 miles

  • Mobil

    1.09 miles

  • Tesla Supercharger

    1.19 miles

  • Sunoco

    1.20 miles

  • Tesla Destination Charger

    1.32 miles

  • The Colonnade Hotel

    1.47 miles

  • Gulf

    1.60 miles

  • Fenced lot, Cherry & School st.'s

    0.15 miles

  • University Park at MIT Parking Garage

    0.15 miles

  • 158 Mass Ave Lot

    0.19 miles

  • N10 Lot

    0.22 miles

  • MIT Visitor Lot

    0.25 miles

  • City Of Cambridge Parking Lot 5

    0.26 miles

  • Green Street Garage

    0.28 miles

  • N4 Albany Garage

    0.34 miles

  • Ensemble Therapeutics

    0.39 miles

  • MIT Main Lot

    0.40 miles

  • Le Meridien Cambridge-MIT

    0.05 miles

  • 907 Main

    0.10 miles

  • Residence Inn Cambridge

    0.57 miles

  • The Kendall Hotel

    0.60 miles

  • The Amory Guest House

    0.61 miles

  • Boston Marriott Cambridge

    0.64 miles

  • Hyatt Regency Boston / Cambridge

    0.65 miles

  • Courtyard Marriott Boston Cambridge

    0.85 miles

  • The Gryphon House

    0.88 miles

  • Boston Hotel Buckminster

    0.96 miles

  • Target

    0.25 miles

  • H Mart

    0.27 miles

  • Cleenland

    0.31 miles

  • Daily Table

    0.37 miles

  • Whole Foods Market

    0.44 miles

  • Tropical Dimension Food Store

    0.77 miles

  • Brothers Marketplace

    0.80 miles

  • Trader Joe's

    0.82 miles

  • Broadway Market

    1.08 miles

  • Marshalls

    1.11 miles

Contact 300 Massachusetts Avenue
  1. 1Main information
  2. 2Extra information
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