Port St. Lucie, FL Commercial Real Estate for Lease
Search 69 commercial real estate listing(s) for lease in Port St. Lucie, FL, including the latest local availabilities across all property types.
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7041 & 7043 S US Highway 1, River Park, Port St. Lucie, FLSpace Type- Office
For Lease- $23.00/SF/YR
2 spaces available / 2,242 - 2,979 SF -
10570 S US Highway 1, Downtown Port St. Lucie, Port Saint Lucie, FLSpace Type- Office
For Lease- $21.00/SF/YR
1 space available / 1,295 SF -
201 SW Port St Lucie Blvd, Thornhill, Port Saint Lucie, FLSpace Type- Office
For Lease Contact for pricing -
870-910 SW St. Lucie Blvd., Lake Forest Pointe, PSL, FLSpace Type- Retail
For Lease- $45.00/SF/YR
1 space available / 2,496 SF -
Looking for more specific results? Choose your preferred property type

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584 Northwest University Boulevard, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $27.00/SF/YR
1 space available / 4,200 SF -
870-910 SW St. Lucie West Blvd, Westbrook Isles, Port St. Lucie, FL -
7434 S Federal Hwy, Spanish Lakes, Port St. Lucie, FLSpace Type- Office
For Lease- $22.67/SF/YR
1 space available / 1,350 SF -
870 St. Lucie W. Boulevard, Lake Forest Pointe, Port St. Lucie, FLSpace Type- Retail
For Lease- $45.00/SF/YR
1 space available / 3,437 SF -
567 NW Lake Whitney Place, St. Lucie West, Port St. Lucie, FL -
870 St. Lucie W Blvd, Lake Forest Pointe, Port St. Lucie, FLSpace Type
- Health Care
For Lease- $45.00/SF/YR
1 space available / 3,437 SF -
1401-1421 Southwest Biltmore Street, River Park, Port St. Lucie, FLSpace Type- Industrial
For Lease- $1,300.00/SF/MO
2 spaces available / 1,000 SF -
1260 SE Industrial Blvd, Port St. Lucie Industrial Park, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $1,450.00/MO
1 space available / 1,000 SF -
Crosstown Pkwy, Southern Grove, Port St. Lucie, FL -
300 NW Bethany Drive # 320, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $18.00/SF/YR
1 space available / 2,000 SF -
7630 S US Highway 1, Spanish Lakes, Port St. Lucie, FLSpace Type- Retail
For Lease- $23.00/SF/YR
4 spaces available / 928 - 1,849 SF -
Tuckpoint Business Park - 660-664 NW Enterprise Dr, St. Lucie West, Port St. Lucie, FL -
870-910 St Lucie W Blvd, Lake Forest Pointe, Port St. Lucie, FLSpace Type
- Retail
For Lease- $45.00/SF/YR
1 space available / 2,496 SF -
1801 Southeast Hillmoor Drive-Unit A-107, Downtown Port St. Lucie, Port St. Lucie, FLSpace Type- Office
For Lease- $28.00/SF/YR
1 space available / 1,530 SF -
10111 U.S. 1, Morningside, Port St. Lucie, FLSpace Type- Retail
For Lease- $175,000.00/YR
1 space available / 4,352 SF -
585 NW Lake Whitney Place, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $25.00/SF/YR
1 space available / 6,619 SF -
2095 NW Commerce Lakes Dr, Reserve Commerce Park, Port Saint Lucie, FLSpace Type- Flex Space
For Lease- $19.50/SF/YR
2 spaces available / 11,827 SF -
1309 SW Gatlin Boulevard, Oak Hammock, Port St. Lucie, FL -
7448 S. Federal Hwy 1, Spanish Lakes, Port St. Lucie, FLSpace Type- Office
For Lease- $22.67/SF/YR
1 space available / 1,350 SF -
870 St. Lucie W Blvd, Lake Forest Pointe, Port St. Lucie, FL -
NW Lake Whitney Place, St. Lucie West, Port St. Lucie, FL -
270 NW Peacock Blvd #104, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $32.31/SF/YR
1 space available / 1,300 SF -
SW Port St Lucie Blvd, Oak Hammock, Port Saint Lucie, FLSpace Type- Retail
For Lease- $22.00 - $31.00/SF/YR
2 spaces available / 1,165 - 2,124 SF -
7630 South U.S. Highway 1, Spanish Lakes, Port St. Lucie, FLSpace Type- Retail
For Lease- $23.00 - $24.00/SF/MO
4 spaces available / 928 - 1,849 SF -
2100 SE Hillmoor Drive Unit 204A, Eastlake Village, Port St. Lucie, FLSpace Type- Office
For Lease- $29.20/SF/YR
1 space available / 940 SF -
584 NW University Blvd Suite 350 584 Northwest University Boulevard, Port St. Lucie, FL -
8241 Business Park Dr, River Park, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $18.00/SF/MO
1 space available / 2,100 SF -
7121 S US Highway 1, River Park, Port Saint Lucie, FLSpace Type- Retail
For Lease- $12.00 - $14.00/SF/YR
3 spaces available / 8,300 - 21,126 SF