Port St. Lucie, FL Commercial Real Estate for Lease
Search 62 commercial real estate listing(s) for lease in Port St. Lucie, FL, including the latest local availabilities across all property types and find helpful local stats in the Market Overview section below.
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7121 S US Highway 1, River Park, Port Saint Lucie, FLSpace Type- Retail
For Lease- $12.00 - $14.00/SF/YR
3 spaces available / 8,300 - 21,126 SF -
1401-1421 Southwest Biltmore Street, River Park, Port St. Lucie, FLSpace Type- Industrial
For Lease- $1,300.00/SF/MO
2 spaces available / 1,000 SF -
1801 Southeast Hillmoor Drive-Unit A-107, Downtown Port St. Lucie, Port St. Lucie, FLSpace Type- Office
For Lease- $28.00/SF/YR
1 space available / 1,530 SF -
1631 SW Gatlin Blvd, Oak Hammock, Port St. Lucie, FLSpace Type
- Office
For Lease- $25.00/SF/YR
1 space available / 1,288 SF -
Looking for more specific results? Choose your preferred property type

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3203 SW Port St. Lucie Boulevard, Gatlin, Port St. Lucie, FLSpace Type
- Retail
For Lease- $22.00/SF/YR
3 spaces available / 900 - 1,256 SF -
247-295 Port St. Lucie Boulevard, Thornhill, Port St. Lucie, FL
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10753 S US Highway 1, Sandpiper Bay, Port Saint Lucie, FL
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11530 SW Village Pkwy, Southern Grove, Port St. Lucie, FL
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2250 SW Gatlin Blvd, Portofino Isles, Port Saint Lucie, FL
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1260 SE Industrial Blvd, Port St. Lucie Industrial Park, Port Saint Lucie, FLSpace Type
- Industrial
For Lease- $1,450.00/SF/MO
1 space available / 1,000 SF -
1880 SW Fountainview Blvd., The Belmont at St Lucie West, Port St. Lucie, FL
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2120-2130 SW Gatlin Blvd, Newport Isle, Port St. Lucie, FL
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648 Southwest Port Saint Lucie Boulevard, Port St. Lucie, FL
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3201 SW PORT ST LUCIE, Villas of Windmill Point, Port St. Lucie, FL
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10512-10914 Southwest Village Pkwy, Tradition, Port St. Lucie, FL
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US-1 & Saegar Avenue, Lake Charles, Port St Lucie, FL
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SW Becker Rd & SW Village Pkwy, Southern Grove, Port St. Lucie, FL
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9100-9198 US Highway 1, Port St. Lucie Industrial Park, Port St. Lucie, FL
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905 E Prima Vista Blvd, River Park, Port St. Lucie, FL
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12050 SW Tom Mackie Blvd, Southern Grove, Port St. Lucie, FLSpace Type
- Industrial
For Lease- $11.00 - $20.00/SF/YR
8 spaces available / 6,017 - 127,634 SF -
2155 Settle Avenue, Reserve Commerce Park, Port St. Lucie, FLSpace Type
- Industrial
For Lease- $16.00/SF/YR
1 space available / 1,700 SF -
Hegener Dr, Southern Grove, Port St. Lucie, FL
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501 Southwest Port Saint Lucie Boulevard, Oak Hammock, Port St. Lucie, FLSpace Type
- Office
For Lease- $24.00/SF/YR
1 space available / 1,000 SF -
200 SW Peacock Blvd Port St, Lake Charles, Port St. Lucie, FL
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7528 US-1, Spanish Lakes, Port St. Lucie, FLSpace Type
- Retail
For Lease- $21.00/SF/YR
4 spaces available / 1,283 - 1,750 SF -
7528 US-1, Spanish Lakes, Port St. Lucie, FL
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Crosstown Pkwy, Southern Grove, Port St. Lucie, FL
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1125 SE Port St. Lucie Blvd, Morningside, Port St. Lucie, FLSpace Type
- Retail
For Lease- $20.00 - $27.08/SF/YR
2 spaces available / 1,000 - 2,400 SF -
St Lucie West, St. Lucie West, Port St. Lucie, FL
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1333 St Lucie W Blvd, St. Lucie West, Port St. Lucie, FL