Please provide a location to search for

South San Francisco, CA Office Space for Rent

  • 2400 Westborough Blvd - South San Francisco
    2400 Westborough Blvd, North Westborough, South San Francisco, CA 94080
    For Lease $2.75/Sqft/Month
    Property
    • Office
    Availability
    • 1 Space
    • 1,011 Sqft
  • The Gateway Technology Center - 630 Gateway Blvd - South San Francisco
    630 Gateway Blvd, The East Side, South San Francisco, CA 94080
    For Lease $66/Sqft/Year
    Property
    • Office
    Availability
    • 1 Space
    • 50,160 Sqft
  • Gateway Commons - S San Francisco
    611 Gateway Blvd, Gateway, S San Francisco, CA 94080
    For Lease $45/Sqft/Year
    Property
    • Office
    Availability
    • 1 Space
    • 13,943 Sqft
  • The Gateway Technology Center - 600 Gateway Blvd - South San Francisco
    600 Gateway Blvd, The East Side, South San Francisco, CA 94080
    For Lease $5.75/Sqft/Month
    Property
    • Office
    Availability
    • 2 Spaces
    • 14,000 Sqft
  • The Gateway Technology Center - 650 Gateway Blvd - South San Francisco
    650 Gateway Blvd, The East Side, South San Francisco, CA 94080
    For Lease $66/Sqft/Year
    Property
    • Office
    Availability
    • 1 Space
    • 50,400 Sqft
  • 400 Oyster Point Blvd - South San Francisco
    400 Oyster Point Blvd, Oyster Point, South San Francisco, CA 94080
    For Lease $33/Sqft/Year
    Property
    • Office
    Availability
    • 1 Space
    • 2,314 Sqft
  • 7000 Shoreline Court - South San Francisco
    7000 Shoreline Court, Paradise Valley, South San Francisco, CA 94080
    For Lease $84/Sqft/Year
    Property
    • Office
    Availability
    • 3 Spaces
    • 39,430 Sqft
  • 701 Gateway - South San Francisco
    701 Gateway Blvd, Gateway, South San Francisco, CA 94080
    For Lease $4.5/Sqft/Month
    Property
    • Office
    Availability
    • 1 Space
    • 9,655 Sqft
  • 701 Gateway - S San Francisco
    701 Gateway Blvd, Gateway, S San Francisco, CA 94080
    For Lease $39/Sqft/Year
    Property
    • Office
    Availability
    • 1 Space
    • 4,293 Sqft
  • Genesis - North Tower - South San Francisco
    2 Tower Place, Paradise Valley, South San Francisco, CA 94080
    For Lease $69/Sqft/Year
    Property
    • Office
    Availability
    • 3 Spaces
    • 34,267 Sqft
  • Oyster Point Marina Plaza I - S San Francisco
    400 Oyster Point Blvd, Oyster Point, S San Francisco, CA 94080
    For Lease $40.8 - $42/Sqft/Year
    Property
    • Office
    Availability
    • 18 Spaces
    • 30,074 Sqft
  • 90 South Spruce - S San Francisco
    90 Spruce Ave, S., Orange Park, S San Francisco, CA 94080
    For Lease $25.8 - $33/Sqft/Year
    Property
    • Industrial
    Availability
    • 4 Spaces
    • 5,202 Sqft
  • 601 Gateway - South San Francisco
    601 Gateway Blvd, Gateway, South San Francisco, CA 94080
    For Lease $48/Sqft/Year
    Property
    • Office
    Availability
    • 1 Space
    • 4,987 Sqft
  • Oyster Point Marina Plaza II - S San Francisco
    395 Oyster Point Blvd, Oyster Point, S San Francisco, CA 94080
    For Lease Contact for pricing
    Property
    • Office
    Availability
    • 17 Spaces
    • 95,275 Sqft
  • 405 Victory Avenue - South San Francisco
    405 Victory Avenue, Lindenville, South San Francisco, CA 94080
    For Lease $16.2 - $18.6/Sqft/Year
    Property
    • Industrial
    Availability
    • 6 Spaces
    • 129,208 Sqft
  • 100-130 Produce Avenue - South San Francisco
    100 Produce Avenue, Lindenville, South San Francisco, CA 94080
    For Lease $9.6 - $19.5/Sqft/Year
    Property
    • Office
    Availability
    • 2 Spaces
    • 3,917 Sqft
  • The Cove at Oyster Point III - South San Francisco
    151 Oyster Point Blvd, Oyster Point, South San Francisco, CA 94080
    For Lease Contact for pricing
    Property
    • Office
    Availability
    • 1 Space
    • 15,241 Sqft
  • The Gateway North Campus - 951 Gateway Blvd - South San Francisco
    951 Gateway Blvd, Gateway, South San Francisco, CA 94080
    For Lease Contact for pricing
    Property
    • Office
    Availability
    • 2 Spaces
    • 39,000 Sqft
  • Airport Boulevard - South San Francisco
    11 Airport Blvd, Lindenville, South San Francisco, CA 94080
    For Lease Contact for pricing
    Property
    • Office
    Availability
    • 6 Spaces
    • 6,661 Sqft
  • Produce Avenue - South San Francisco
    100 Produce Avenue, Lindenville, South San Francisco, CA 94080
    For Lease Contact for pricing
    Property
    • Office
    Availability
    • 4 Spaces
    • 8,199 Sqft

Explore Office Listings in South San Francisco, CA

Our current local inventory includes 38 listings. Explore options of office spaces for rent in South San Francisco, CA across all local neighborhoods and submarkets. Listings presented on our network comprise a wide variety of sizes, as well as an abundance of property classes, amenities and location advantages. Access property details and listing information; get contact details and pricing; and find highlights and points of interest in the region.

Easy-to-use search tools and filters allow you to quickly and conveniently browse our South San Francisco, CA office space for rent listings. Navigate the interactive map to view office listings by ZIP code, neighborhood or radius. Or, browse along a corridor or route of interest with the “current view” mode. Check out similar office spaces in the area and find your perfect place.

Top 10 Largest Office Buildings

in South San Francisco

Office building Address Sqft Year built
Genentech Headquarters - Lower Main Campus 1 DNA Way, 94080 1,408,361 1970
Kilroy Oyster Point - Phase I 379 Oyster Point Blvd, 94080 656,000 2021
Gateway of Pacific I 1000 Gateway Blvd, 94080 510,000 2021
Gateway of Pacific II 750 Gateway Blvd, 94080 440,000 2021
Genesis - North Tower 2 Tower Place, 94080 381,523 2018
Gateway of Pacific III 700 Gateway Blvd, 94080 360,000 2021
201 Haskins Way 201 Haskins Way, 94080 311,369 2021
The Merck Campus 221 East Grand Avenue, 94080 294,000 2019
Genentech Headquarters - Mid Main Campus - Buildings 13-15 340 Point San Bruno Blvd, 94080 277,814 2003
Genentech Headquarters - Mid Main Campus - Buildings 10-12 & 36 99 DNA Way, 94080 276,044 1975

Largest Office Properties Recently Completed

in South San Francisco

Office building Address Sqft Year built
Kilroy Oyster Point - Phase I 379 Oyster Point Blvd, 94080 656,000 2021
Gateway of Pacific I 1000 Gateway Blvd, 94080 510,000 2021
Gateway of Pacific II 750 Gateway Blvd, 94080 440,000 2021
Gateway of Pacific III 700 Gateway Blvd, 94080 360,000 2021
201 Haskins Way 201 Haskins Way, 94080 311,369 2021
The Cove at Oyster Point V 181 Oyster Point Blvd, 94080 164,150 2020
The Merck Campus 221 East Grand Avenue, 94080 294,000 2019
279 East Grand Avenue 279 East Grand Avenue, 94080 211,405 2019
The Cove at Oyster Point VII 131 Oyster Point Blvd, 94080 175,830 2019
Britannia East Grand: Genentech Headquarters - South Campus - Building 40 500 East Grand Avenue, 94080 160,582 2019

News

Industrial property construction picked up significantly in 2020 to meet the notable increase in demand, nearly doubling industrial project completions recorded in 2019.

When the Shoreline Square tower first earned LEED Gold certification in 2015, it was the only LEED Gold multi-tenant office building in town certified under the EBO+M Rating system.

Intercontinental Real Estate Corp. makes its first foray into the Los Angeles industrial real estate market, with the acquisition of a fully-leased last-mile distribution facility in Chatsworth.