Sienna Medical Plaza

For Lease

8102 Hwy 6, Missouri City, TX 77459

The total number of office spaces available at Sienna Medical Plaza is 1. Leasing opportunities in the building include medical office. There is a total of 18,400 square feet of space currently available for rent at this address. Of this, the minimum divisible area is 18,400 square feet.

Space Available For Lease 1

Contacts

Kris Bender

Realty 1 Partners

Property Details

  • Property Type Office - Medical Office
  • Year Built 2025
  • Date Updated May 17, 2026

Sienna Medical Plaza is a newly delivered, two-story, 36,800 SF Class A medical office building strategically positioned along Highway 6 in the heart of the Sienna master-planned community in Missouri City, Texas. The property is purpose-built for healthcare and anchored by MD Anderson Cancer Center, which occupies the entire first floor, immediately establishing the building as a recognized medical destination within Fort Bend County.

The available opportunity consists of the full 18,400 SF second floor, offering a contiguous, efficient floor plate designed to accommodate specialty medical, imaging, infusion, oncology support, women’s health, surgical consult, therapy, and other referral-based healthcare providers. Elevator-served and fully sprinklered, the building provides institutional quality construction and professional lobby access, delivering the identity and functionality today’s medical operators require.

Sienna is one of the fastest-growing master-planned communities in the Houston MSA, with significant residential density and strong household incomes surrounding the site. The property benefits from direct exposure and access along Highway 6, a primary north-south arterial serving Missouri City and greater Fort Bend County. This corridor continues to experience sustained population growth, creating long-term demand for healthcare services and specialty providers.

The presence of MD Anderson on-site creates immediate referral synergy, daily patient traffic, and long-term stability for complementary medical users. Opportunities to lease directly above a nationally recognized healthcare institution within a newly constructed, Class A facility are rare in this submarket

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Highlights

  • 18,400 SF Contiguous 2nd Floor Divisible for Strategic Users
  • Anchored by MD Anderson Cancer Center (Entire 1st Floor Leased)
  • Class A, Two-Story Purpose-Built Medical Construction
  • Efficient Floor Plate Ideal for Specialty & Clinical Layouts
  • Elevator-Served with Professional Healthcare Lobby
  • Positioned Within Rapidly Expanding Sienna Master-Planned Community
  • Prominent Highway 6 Visibility & Access
  • Rare Institutional-Quality Medical Asset in Sienna Corridor

Getting around

  • 47/100

    Walk Score ®

  • 41/100

    Bike Score ®

Powered by Walk Score ®

Location

  • City Missouri City, TX
  • Neighborhood Sienna Village Of Anderson Springs
  • Zip Code 77459
  • Market Houston

Points of Interest

  • Exxon

    0.74 miles

  • H-E-B Fuel

    0.82 miles

  • Shell

    1.25 miles

  • Chevron

    1.80 miles

  • Kroger

    2.15 miles

  • Walmart

    2.36 miles

  • eVgo

    5.84 miles

  • Tesla Supercharger

    5.95 miles

  • Richmond, TX Supercharger

    8.91 miles

  • Blink

    9.98 miles

  • Kroger Pickup

    2.17 miles

  • Missouri City Park and Ride

    5.90 miles

  • Sugar Land Parking Lot 3

    6.42 miles

  • Sugar Land Parking Lot 4

    6.43 miles

  • Albert & Mamie George Building Loading Dock

    6.47 miles

  • Sugar Land Parking Lot 2

    6.54 miles

  • Day Lot 3

    6.56 miles

  • Brazos Hall Loading Dock

    6.57 miles

  • Day Lot

    6.58 miles

  • Sugar Land Parking Lot 1

    6.59 miles

  • Fairfield Inn & Suites Houston Missouri City

    1.90 miles

  • SummerHill inn & Suites

    2.13 miles

  • Holiday Inn Express & Suites Sugar Land SE - Missouri City, an IHG Hote

    2.82 miles

  • Hampton Inn & Suites Missouri City, TX

    2.92 miles

  • Mustang Inn & Suites

    5.67 miles

  • Sugar Land Marriott Town Square

    5.72 miles

  • Hyatt Place Houston/Sugar Land

    6.05 miles

  • Courtyard Houston Sugar Land/Lake Pointe

    6.08 miles

  • Drury Inn & Suites Houston Sugar Land

    6.29 miles

  • Fondren Inn

    6.34 miles

  • ALDI

    0.11 miles

  • H-E-B

    0.90 miles

  • Kroger

    1.66 miles

  • Goodwill Retail Store

    1.66 miles

  • Target

    1.86 miles

  • Walmart Supercenter

    2.01 miles

  • Kohl's

    2.34 miles

  • Welfresh Market

    3.36 miles

  • Fiesta Mart Supermarket

    3.90 miles

  • Big Lots

    4.39 miles

8102 Hwy 6 Listing Brief

  • Leasing rates here can depend on a variety of factors, including the quality rating of the property (property class or building class), the position of the available space within the building, any unique attributes that the listed space may include, as well as on the availability of on-site or nearby amenities. Reach out using the contact form available on this page to schedule a tour or to get more detailed information on the most modern facilities and amenities that 8102 Hwy 6 has to offer.

  • See the listing area details for information and ratings regarding the degree of walkability in the neighborhood, the accessibility and frequency of public transit options, as well as the level of availability and quality of biking infrastructure in the area. What’s more, you can use the interactive map for a good overview of the area. Location details also include a breakdown of distance from the property to several essential amenities and points of interest, which may include parking facilities, fuel stations, stores, or hotels.

  • This property is in the Sienna Village Of Anderson Springs neighborhood of Missouri City and located within zip code 77459.

    The building includes 0 square feet, of which 18,400 square feet is rentable office space.

Contact Listing Broker
Kris Bender

Realty 1 Partners

  1. 1Main information
  2. 2Extra information
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