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Property Details
- Property Type Office - General Office
- Property Size 13,139 SF
- Lot Size 3.98 SF
- Date Updated Jun 9, 2025
Two Medical Buildings Investment Opportunity
Located at 56 and 80 Hwy 321 Bypass N in Winnsboro, South Carolina, this investment opportunity includes two medical office buildings with ±3,646 SF vacancy and excess land, providing additional possibilities for growth and development.
Tenant Overview
Prisma Health is South Carolina’s largest not-for-profit health system, focused on improving the health of residents. In Winnsboro, they operate a Family Medicine clinic at 56 US Highway 321 Bypass North, offering primary care services for all ages.
Prisma Health Orthopedics Rehabilitation–Winnsboro, located at 80 US Highway 321 Bypass North, provides physical and occupational therapy for orthopedic injuries, with personalized rehabilitation programs to aid recovery and improve mobility.
Location Overview
The properties are centrally located in Fairfield County and situated ±7.8 miles to Interstate 77, ±15.9 miles to Blythewood and ±14.9 miles to Scout Motors development —a $2B development expected to create over 4,000 permanent jobs.
For more information, download the flyer and contact the listing broker, Matthew Pollard.
Reach out to the broker for more info on lease terms and amenities
Attachments
Getting around
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Location
- City Winnsboro, SC
- Zip Code 29180
- Market Columbia
Points of Interest
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Gas of India
2.28 miles
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Exxon
7.05 miles
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Americas Best Value Inn
1.87 miles
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Food Lion
1.69 miles
Access more in-depth information about this property — including ownership, tenant details, property characteristics and transaction history, along with local market insights and much more — on CommercialEdge.

Colliers