321 Main Street Seneca SC

For Lease

321 Main Street, Seneca, SC 29678

You can currently find 1 retail space(s) available for lease at 321 Main Street Seneca SC. Designated use type for space listed here includes street retail. Current retail listings at this property total 2,600 square feet. Lease type options include NNN. Expand the listing and property details below for additional information on leasing opportunities at 321 Main Street Seneca SC.

Space Available For Lease 1

Contacts

Eddie Smith

McCoy Wright

Property Details

  • Property Type Retail - Street Retail
  • Property Size 5,500 SF
  • Units 1
  • Date Updated Jun 15, 2026
Downtown Seneca, SC.For Lease a 2,600 SF retail space located at 321 Main Street in the heart of downtown Seneca. The space is in excellent condition and can be easily adapted for use as a restaurant, bar, office or retail. One of two commercial units in a building set in Historic Downtown Seneca. This location offers 34’ frontage on Main Street with street-to-street access to the rear on West North First Street. This space offers an open floor plan with restrooms and storage in the back. The property is located inside city limits and is zoned commercial by the city of Seneca. There is ample parking and a municipal lot directly across Main. The unit is fully heated and air-conditioned with private entrance and restroom facilities. The asking price is $20/SF NNN. This location is close to all city activities including the popular Ram Cat Alley, the new Performing Arts Center and open-air amphitheater. Contact Listing agents with any interest or to schedule a showing.
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Attachments

Getting around

  • 60/100

    Walk Score ®

  • 35/100

    Bike Score ®

Powered by Walk Score ®

Location

  • City Seneca, SC
  • Neighborhood Seneca
  • Zip Code 29678
  • Market Greenville

Points of Interest

  • Xpress

    0.16 miles

  • Marathon

    1.04 miles

  • QuikTrip

    1.16 miles

  • Ingles Gas Express

    1.28 miles

  • Stop-A-Minit

    2.60 miles

  • Exxon

    2.81 miles

  • 7-Eleven

    4.15 miles

  • Sunoco

    6.15 miles

  • Bus Lot

    4.61 miles

  • Seneca Creek Boat Ramp

    4.80 miles

  • E-7

    5.81 miles

  • C-15

    5.83 miles

  • P-4

    5.88 miles

  • C-3

    5.95 miles

  • R-3

    6.03 miles

  • E-14

    6.16 miles

  • C-2

    6.17 miles

  • E-5

    6.26 miles

  • G's Pizza House

    0.06 miles

  • Ye Olde Sandwich Shoppe

    0.14 miles

  • Bistro 24

    0.15 miles

  • Vangeli's Restaurant

    0.19 miles

  • Bonaterra

    0.19 miles

  • Alley Dogs

    0.23 miles

  • Strickland's

    0.38 miles

  • Dimas Bros. Cafe

    0.51 miles

  • Seneca Family Restaurant

    0.80 miles

  • Copper River Grill

    0.90 miles

  • Publix

    1.37 miles

  • Ingles

    1.39 miles

  • Food Lion

    1.91 miles

  • ALDI

    2.24 miles

  • Belk

    2.32 miles

  • Walmart Supercenter

    2.77 miles

  • Marshalls

    5.27 miles

321 Main Street Listing Brief

  • A property’s location contributes to the asking rent almost as much as its characteristics do. For instance, central urban locations with high walkability or suburban locations with ample parking and easy access by car will claim higher rents but offer superior access to your customer base. Likewise, the quality of the building systems and property finishes have a significant impact on how businesses can conduct their activity there, as well as on the experience of their customers.

    Retail space at 321 Main Street Seneca SC asks $20.00/SF/YR per square foot.

  • The property includes 2,600 square feet of retail space for lease. Of this total, 2,600 square feet are Street Retail.

    Lease agreement conditions for the availability at this property include NNN.

    For more information or to schedule a tour of the property, use the convenient contact form on this page to get in touch with a representative.

  • You should keep in mind that different areas gradually build a reputation as hotspots or desirable corridors for shopping, eating, or other entertainment and consumer activities. So, while renting retail space in an area with a well-established high-end reputation might mean more customers that are more willing to spend, it will also place you in a more competitive environment.

Contact Listing Broker
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