Price of Retail Space for Lease at 221 N Main St

A property’s location contributes to the asking rent almost as much as its characteristics do. For instance, central urban locations with high walkability or suburban locations with ample parking and easy access by car will claim higher rents but offer superior access to your customer base. Likewise, the quality of the building systems and property finishes have a significant impact on how businesses can conduct their activity there, as well as on the experience of their customers. 221 N Main St is located in Downtown Greenville, which is home to a total of 14 listing(s). The rent for retail space at 221 N Main St is available upon request. Feel free to reach out using the contact form conveniently included on this page to find out more about what the property can offer for your business.

Type of Retail Space for Lease at 221 N Main St

The property includes 13,000 square feet of retail space for lease. Of this total, 13,000 square feet are Restaurant. For more information or to schedule a tour of the property, use the convenient contact form on this page to get in touch with a representative.

Amenities and Perks of Leasing Retail Space at 221 N Main St

You should keep in mind that different areas gradually build a reputation as hotspots or desirable corridors for shopping, eating, or other entertainment and consumer activities. So, while renting retail space in an area with a well-established high-end reputation might mean more customers that are more willing to spend, it will also place you in a more competitive environment. Knowing your ideal customer is essential. For your consideration, the average age of residents in Downtown Greenville is 41. The average household income here is $76,136 per year.

221 N Main St, Greenville, SC 29601

Space Available For Lease 1

Full Building

Space Type Restaurant
Lease Rate Contact for pricing
Total Space Available 13,000 SF
Max Contiguous 13,000 SF
Available Date Immediate
Renewal Option Yes
Sublease No

Second generation restaurant space with hood system, kitchen equipment etc.
Amazing downtown location across the street from The Hyatt
Street level storefront entrance and street level staircase access that leads to the 2nd floor
Over ±70 retail and restaurants within 1 mile
Features exposed brick, high ceilings, large windows and an elevator
Basement, ground floor with large open space and kitchen, mezzanine level with restrooms and bar, and a second floor with large open space
Multiple restrooms and bars throughout and multiple access points to Main Street and the alley behind
Up to $250,000 available with facade improvement grant for exterior renovations from the City of Greenville.
Possibility to reinforce the structure and create a roof top component
Zoned: MXS-D (City of Greenville)

Entire ±13,000 SF building is available for lease located on Main Street in Downtown Greenville. The building is also able to be subdivided – inquire for details. The layout features a large basement, street level, mezzanine, second floor with multiple staircases, entry/exits.

Signage Yes
Signage Options Building

Zach Hines

Spencer/Hines Properties

Cameron Smith Weber

Spencer/Hines Properties

Contacts

Zach Hines

Spencer/Hines Properties

Cameron Smith Weber

Spencer/Hines Properties

Property Details

Property Type Retail - Restaurant
Property Size 13,000 SF
Date Updated Apr 24, 2026

Second generation restaurant space with hood system, kitchen equipment etc.
Amazing downtown location across the street from The Hyatt
Street level storefront entrance and street level staircase access that leads to the 2nd floor
Over ±70 retail and restaurants within 1 mile
Features exposed brick, high ceilings, large windows and an elevator
Basement, ground floor with large open space and kitchen, mezzanine level with restrooms and bar, and a second floor with large open space
Multiple restrooms and bars throughout and multiple access points to Main Street and the alley behind
Up to $250,000 available with facade improvement grant for exterior renovations from the City of Greenville.
Possibility to reinforce the structure and create a roof top component
Zoned: MXS-D (City of Greenville)

Entire ±13,000 SF building is available for lease located on Main Street in Downtown Greenville. The building is also able to be subdivided – inquire for details. The layout features a large basement, street level, mezzanine, second floor with multiple staircases, entry/exits.

Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

Getting around

90/100
Walk Score ®
32/100
Transit Score ®
83/100
Bike Score ®

Powered by Walk Score ®

Location

City Greenville, SC
Neighborhood Downtown Greenville
Zip Code 29601
Market Greenville

Points of Interest

Fast Charger

0.08 miles
QuikTrip

0.55 miles
Shell

0.59 miles
Marathon

0.94 miles
ChargePoint

0.98 miles
Spinx

1.04 miles
Texaco

1.16 miles
Circle K

1.36 miles
GT's Express Mart

1.44 miles
Citgo

1.74 miles

Mall 200 Municipal Parking

0.03 miles
Lanier Parking

0.07 miles
Condustrial Parking

0.07 miles
Visitor 110 W North St

0.08 miles
Daniel Building Parking

0.10 miles
Richardson Street Parking

0.10 miles
Greenville Commons Municipal Parking

0.11 miles
201 E North parking

0.12 miles
BS UMC Parking

0.13 miles

Kilpatrick's Public House

0.01 miles
Menkoi Udon and Soba

0.03 miles
Roost

0.04 miles
Bertolo's Pizza

0.04 miles
Sushi Koji

0.05 miles
Cafe and Then Some

0.07 miles
Fresh Salads Etc

0.08 miles
Maple Street Biscuit Company

0.09 miles
Lost Cajun

0.09 miles
Jack n' Diane's Dueling Pianos

0.10 miles

Mast General Store

0.08 miles
Publix

0.42 miles
Harris Teeter

0.90 miles
Educators' Marketplace

1.99 miles
The Fresh Market

2.16 miles
Saigon Market

2.19 miles
ALDI

2.37 miles
Ingles

2.41 miles
Ross

2.45 miles
Burlington

2.54 miles

221 N Main St Listing Brief

A property’s location contributes to the asking rent almost as much as its characteristics do. For instance, central urban locations with high walkability or suburban locations with ample parking and easy access by car will claim higher rents but offer superior access to your customer base. Likewise, the quality of the building systems and property finishes have a significant impact on how businesses can conduct their activity there, as well as on the experience of their customers.

221 N Main St is located in Downtown Greenville, which is home to a total of 14 listing(s). The rent for retail space at 221 N Main St is available upon request. Feel free to reach out using the contact form conveniently included on this page to find out more about what the property can offer for your business.
The property includes 13,000 square feet of retail space for lease. Of this total, 13,000 square feet are Restaurant.

For more information or to schedule a tour of the property, use the convenient contact form on this page to get in touch with a representative.
You should keep in mind that different areas gradually build a reputation as hotspots or desirable corridors for shopping, eating, or other entertainment and consumer activities. So, while renting retail space in an area with a well-established high-end reputation might mean more customers that are more willing to spend, it will also place you in a more competitive environment.

Knowing your ideal customer is essential. For your consideration, the average age of residents in Downtown Greenville is 41. The average household income here is $76,136 per year.

Map of Property

221 N Main St