22 South Main Street

For Lease

22 South Main Street, Greenville, SC 29601

The total number of office spaces available at 22 South Main Street is 1. Leasing opportunities in the building include retail. There is a total of 8,500 square feet of space currently available for rent at this address. Of this, the minimum divisible area is 8,500 square feet.

Space Available For Lease 1

Contacts

Laurens Nicholson

Windsor Aughtry

Cortney Carter

Collett

Property Details

  • Property Type Office - General Office
  • Property Size 46,092 SF
  • Lot Size 0.22 Acre
  • Property Tenancy Multi-Tenant
  • Building Class C
  • Year Built 1947
  • Date Updated Apr 20, 2026
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Reach out to the broker for more info on lease terms and amenities

Getting around

  • 86/100

    Walk Score ®

  • 32/100

    Transit Score ®

  • 84/100

    Bike Score ®

Powered by Walk Score ®

Location

  • City Greenville, SC
  • Neighborhood Downtown Greenville
  • Zip Code 29601
  • Market Greenville

Points of Interest

  • Fast Charger

    0.16 miles

  • QuikTrip

    0.69 miles

  • Marathon

    0.73 miles

  • ChargePoint

    0.77 miles

  • Shell

    0.82 miles

  • Spinx

    1.21 miles

  • Texaco

    1.29 miles

  • Circle K

    1.57 miles

  • GT's Express Mart

    1.64 miles

  • Harvey's

    1.72 miles

  • West Washington Parking Deck

    0.05 miles

  • Poinsett Parking Garage

    0.08 miles

  • South Spring Street Garage

    0.11 miles

  • City Hall Visitor parking

    0.13 miles

  • First Presbyterian Church Parking

    0.14 miles

  • Richardson Street Parking

    0.15 miles

  • River Street Garage

    0.17 miles

  • BS UMC Parking

    0.20 miles

  • Visitor 110 W North St

    0.20 miles

  • Aloft

    0.09 miles

  • The Westin Poinsett Hotel

    0.09 miles

  • SpringHill Suites

    0.16 miles

  • Courtyard Greenville Downtown

    0.17 miles

  • AC Hotel

    0.22 miles

  • Hyatt Regency Greenville

    0.26 miles

  • Embassy Suites

    0.26 miles

  • Hyatt Place

    0.27 miles

  • Hampton Inn & Suites Greenville-Downtown-RiverPlace

    0.32 miles

  • Home2 Suites

    0.33 miles

  • Mast General Store

    0.14 miles

  • Publix

    0.31 miles

  • Harris Teeter

    1.10 miles

  • The Fresh Market

    2.18 miles

  • Educators' Marketplace

    2.19 miles

  • Saigon Market

    2.39 miles

  • Deal Mart

    2.42 miles

  • Food Lion

    2.44 miles

  • ALDI

    2.58 miles

  • Ingles

    2.61 miles

22 South Main Street Listing Brief

  • Leasing rates here can depend on a variety of factors, including the quality rating of the property (property class or building class), the position of the available space within the building, any unique attributes that the listed space may include, as well as on the availability of on-site or nearby amenities. Reach out using the contact form available on this page to schedule a tour or to get more detailed information on the most modern facilities and amenities that 22 South Main Street has to offer.

  • See the listing area details for information and ratings regarding the degree of walkability in the neighborhood, the accessibility and frequency of public transit options, as well as the level of availability and quality of biking infrastructure in the area. What’s more, you can use the interactive map for a good overview of the area. Location details also include a breakdown of distance from the property to several essential amenities and points of interest, which may include parking facilities, fuel stations, stores, or hotels.

  • This property is in the Downtown Greenville neighborhood of Greenville and located within zip code 29601.

    22 South Main Street was originally completed in 1947 and is rated class C. The building includes 46,092 square feet, of which 8,500 square feet is rentable office space.

Contact 22 South Main Street
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