4100 N. Main Street

For Lease

4100 N. Main Street, Columbia, SC 29203

The total number of office spaces available at 4100 N. Main Street is 3. Leasing opportunities in the building include office. There is a total of 6,226 square feet of space currently available for rent at this address. Of this, the minimum divisible area is 1,226 square feet.

Space Available For Lease 3

Contacts

Roger Winn

Trinity Partners

Property Details

  • Property Type Office - General Office
  • Property Size 18,937 SF
  • Lot Size 1.3 Acre
  • Building Class B
  • Year Built 1987
  • Year Renovated 2019
  • Date Updated Jun 24, 2026
Located on North Main Street in North Columbia near the revitalized NOMA district. Easy access to downtown Columbia, I-26, I-277 and a few miles from I-20.Turnkey Medical Office Space Ranging from 1,226 SF up to 3,742 SF
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Highlights

  • Located in Columbia's growing North Main (NOMA) corridor
  • Major renovations in 2019 included a new roof, building façade, and common area upgrades
  • Suite 101: ±2,484 SF available 8/1/26
  • Suite 200: ±1,226 SF with reception area, 3 exam rooms (with plumbing), 1 private office, and restroom
  • Suite 201: ±2,516 SF with large reception/waiting area, 6 exam rooms with plumbing, 2 private offices, IT and storage rooms, and restroom

Getting around

  • 63/100

    Walk Score ®

  • 32/100

    Transit Score ®

  • 37/100

    Bike Score ®

Powered by Walk Score ®

Location

  • City Columbia, SC
  • Neighborhood Seminary Ridge
  • Zip Code 29203
  • Market Columbia

Points of Interest

  • Columbia

    3.15 miles

  • Sunoco

    0.30 miles

  • Speedway

    0.51 miles

  • Shell

    0.84 miles

  • Marathon

    1.90 miles

  • Exxon

    1.90 miles

  • BP

    1.92 miles

  • Flying J

    1.95 miles

  • Columbia, SC Supercharger

    6.86 miles

  • Columbia, SC - Harbison Boulevard Supercharger

    7.04 miles

  • Circle K

    8.96 miles

  • Prisma Health Baptist Hospital Parking

    2.24 miles

  • P. Cannon Garage

    2.27 miles

  • Taylor Street Garage

    2.30 miles

  • Parking of CSH

    2.43 miles

  • AD7 Lot

    2.47 miles

  • Lady Street Parking Garage

    2.65 miles

  • AD12

    2.95 miles

  • B6 Lot

    3.00 miles

  • 901 Park St Garage

    3.01 miles

  • Park View Inn

    0.79 miles

  • Super 8 by Wyndham Columbia

    1.86 miles

  • Glass Manor

    1.94 miles

  • Staybridge Suites

    2.30 miles

  • Hotel Trundle

    2.31 miles

  • Columbia Marriott

    2.41 miles

  • Coronet

    2.43 miles

  • Holiday Inn Columbia - Downtown

    2.46 miles

  • Sheraton Columbia Downtown Hotel

    2.48 miles

  • Suburban Extended Stay Hotel

    2.54 miles

  • Food Lion

    1.15 miles

  • Uncle Willie's Grocery Store

    1.72 miles

  • Piggly Wiggly

    2.38 miles

  • Market Place Shopping Center

    2.82 miles

  • Publix

    2.88 miles

  • Halal International

    2.92 miles

  • Asian Market

    3.01 miles

  • Burlington

    3.03 miles

  • Kroger

    3.10 miles

  • Dutch Square Mall

    3.10 miles

4100 N. Main Street Listing Brief

  • Leasing rates here can depend on a variety of factors, including the quality rating of the property (property class or building class), the position of the available space within the building, any unique attributes that the listed space may include, as well as on the availability of on-site or nearby amenities. Reach out using the contact form available on this page to schedule a tour or to get more detailed information on the most modern facilities and amenities that 4100 N. Main Street has to offer.

  • See the listing area details for information and ratings regarding the degree of walkability in the neighborhood, the accessibility and frequency of public transit options, as well as the level of availability and quality of biking infrastructure in the area. What’s more, you can use the interactive map for a good overview of the area. Location details also include a breakdown of distance from the property to several essential amenities and points of interest, which may include parking facilities, fuel stations, stores, or hotels.

  • This property is in the Seminary Ridge neighborhood of Columbia and located within zip code 29203.

    4100 N. Main Street was originally completed in 1987 and is rated class B. The building includes 18,937 square feet, of which 6,226 square feet is rentable office space. The most recent renovation completed at this address was in 2019.

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