CLASS A OFFICE SPACE AVAILABLE WITHIN THE HUB OF THE CORTEX INNOVATION DISTRICT

For Lease

4220 Duncan Ave, St. Louis, MO 63110

The total number of office spaces available at CLASS A OFFICE SPACE AVAILABLE WITHIN THE HUB OF THE CORTEX INNOVATION DISTRICT is 1. Leasing opportunities in the building include general office. There is a total of 11,391 square feet of space currently available for rent at this address. Of this, the minimum divisible area is 7,707 square feet.

Space Available For Lease 1

Contacts

Tony Kennedy

Colliers

Rebekah Bahn Kingston

Colliers

Property Details

  • Property Type Office - General Office
  • Building Class A
  • Year Built 2018
  • Date Updated May 23, 2026

4220 Duncan is an expanded venue for innovation and entrepreneurism for small and large companies seeking to locate in the hub of the St. Louis life science and technology marketplace.

Suite 303:

  • 7,707 SF Office Space Available
  • Plug and Play Condition
  • Move-in Ready
  • Large Training Room

 

Suite 403:

  • 11,391 SF Office Space Available
  • Plug and Play Condition
  • Move-in Ready
  • New Furniture Included
  • Prime Elevator Lobby Entrance

 

Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

Getting around

  • 80/100

    Walk Score ®

  • 58/100

    Transit Score ®

  • 67/100

    Bike Score ®

Powered by Walk Score ®

Location

  • City St. Louis, MO
  • Neighborhood Central West End Saint Louis
  • Zip Code 63110
  • Market St Louis

Points of Interest

  • Missouri History Museum/Forest Park

    2.03 miles

  • The Wild Station

    2.09 miles

  • Forest Park - DeBaliviere Metrolink

    2.12 miles

  • Discovery Corner Station

    2.21 miles

  • Union Station - Elevator Access

    2.38 miles

  • Union Station

    2.40 miles

  • Union Station - Stair Access

    2.44 miles

  • St. Louis - Gateway Station

    2.61 miles

  • Delmar Loop Metrolink

    2.77 miles

  • Delmar Loop

    2.81 miles

  • BP

    0.43 miles

  • QuikTrip

    0.46 miles

  • Tesla Supercharger

    1.13 miles

  • ChargePoint

    1.30 miles

  • Mobil

    1.41 miles

  • Crown

    1.49 miles

  • EVgo Charging Station

    2.33 miles

  • EV Connect

    2.92 miles

  • Electric Car Charging Station

    4.02 miles

  • 4220 Duncan Garage

    0.04 miles

  • 4240 and Tech Shop Parking

    0.07 miles

  • Cortex lot

    0.21 miles

  • IKEA Parking Lot

    0.33 miles

  • Chroma Apartments Garage

    0.40 miles

  • American Red Cross Parking Garage

    0.44 miles

  • Duncan/Taylor Parking Garage

    0.49 miles

  • Loyola Parking Lot

    0.49 miles

  • Clayton Avenue Parking Garage

    0.49 miles

  • West Lot

    0.49 miles

  • Aloft by Mariott

    0.13 miles

  • Element St. Louis Midtown

    0.58 miles

  • Home2 Suites by Hilton St. Louis/Forest Park

    0.58 miles

  • DoubleTree by Hilton

    0.68 miles

  • Holiday Inn Express

    0.81 miles

  • AC Hotel St. Louis Central/West End

    0.96 miles

  • The Royal Sonesta Chase Park Plaza St. Louis

    1.00 miles

  • Angad Arts Hotel

    1.12 miles

  • Hotel Ignacio

    1.19 miles

  • Hampton Inn & Suites St. Louis at Forest Park

    1.69 miles

  • N & M Food Market

    0.53 miles

  • Schnucks

    0.55 miles

  • Fresh Thyme

    0.65 miles

  • Whole Foods Market

    0.80 miles

  • Target

    0.93 miles

  • Straub's Market

    1.07 miles

  • ALDI

    1.38 miles

  • Save-A-Lot

    1.45 miles

  • John Viviano and Sons

    1.63 miles

  • DiGregorio's Italian Market

    1.73 miles

4220 Duncan Ave Listing Brief

  • Leasing rates here can depend on a variety of factors, including the quality rating of the property (property class or building class), the position of the available space within the building, any unique attributes that the listed space may include, as well as on the availability of on-site or nearby amenities. Reach out using the contact form available on this page to schedule a tour or to get more detailed information on the most modern facilities and amenities that 4220 Duncan Ave has to offer.

  • See the listing area details for information and ratings regarding the degree of walkability in the neighborhood, the accessibility and frequency of public transit options, as well as the level of availability and quality of biking infrastructure in the area. What’s more, you can use the interactive map for a good overview of the area. Location details also include a breakdown of distance from the property to several essential amenities and points of interest, which may include parking facilities, fuel stations, stores, or hotels.

  • This property is in the Central West End Saint Louis neighborhood of St. Louis and located within zip code 63110.

    4220 Duncan Ave was originally completed in 2018 and is rated class A. The building includes 0 square feet, of which 11,391 square feet is rentable office space.

Contact CLASS A OFFICE SPACE AVAILABLE WITHIN THE HUB OF THE CORTEX INNOVATION DISTRICT
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