SW Rochester Professional Office

Discover a premier office opportunity in the heart of Rochester’s Southwest 2nd Street corridor. Just blocks from Mayo Clinic’s Saint Marys Campus and positioned along the city’s new rapid transit bus route, this stand-alone, Class A building offers unmatched visibility, accessibility, and professional appeal.

Built in 2011 and meticulously maintained, the property features nearly 12,000 square feet of thoughtfully designed space that balances high-end finishes with day-to-day functionality. The flexible layout includes private offices, conference rooms, open work areas, and abundant natural light—delivering a turnkey environment ready to support a wide range of business needs.

With ample on-site parking, impressive curb appeal, and prominent monument signage, this is a prime opportunity for growing organizations that want to stand out. Situated in a high-traffic corridor with immediate access to Highway 52 and Downtown Rochester, 2200 2nd St SW places your business at the forefront of one of the Midwest’s fastest-growing medical and commercial communities. Reach out to schedule your private tour today.