Ruffin Business Center

For Lease

3645 Ruffin Rd. , San Diego, CA 92123

The total number of office spaces available at Ruffin Business Center is 3. Leasing opportunities in the building include office. There is a total of 3,127 square feet of space currently available for rent at this address. Of this, the minimum divisible area is 821 square feet.

Space Available For Lease 3

Contacts

Joshua J. Smith

SVN | Vanguard

Property Details

  • Property Type Office - General Office
  • Property Size 40,000 SF
  • Building Class B
  • Date Updated Aug 4, 2026
Located in Kearny Mesa, one of San Diego’s most established business and commercial districts, this two-building property offers exceptional accessibility and connectivity to major transportation corridors including Interstate 15, Interstate 805, and State Route 163. Positioned near a prominent intersection (Ruffin Rd. & Aero Dr.), the property provides convenient access for employees, clients, and visitors throughout San Diego County. The surrounding area features a strong mix of office, industrial, retail, and dining amenities, making it an ideal business environment for a wide range of professional users. Nearby retailers, restaurants, and service providers contribute to a highly convenient and amenity-rich location within one of Central San Diego’s most active commercial hubs.Elevator served Operable windows Internal Atrium allowing natural light in common areas Business park setting with large shared parking lot Central San Diego Location / Kearny Mesa 0.19 Miles from I-15 off and on ramps Walking distance to retail centers
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Attachments

Getting around

  • 55/100

    Walk Score ®

  • 27/100

    Transit Score ®

  • 34/100

    Bike Score ®

Powered by Walk Score ®

Location

  • City San Diego, CA
  • Neighborhood Kearny Mesa
  • Zip Code 92123
  • Market San Diego

Points of Interest

  • Stadium

    2.01 miles

  • Mission San Diego

    2.07 miles

  • Grantville

    2.40 miles

  • Rio Vista

    2.86 miles

  • Hazard Center

    3.57 miles

  • Uber / Lyft Driver Drop Off

    3.73 miles

  • SDSU Transit Center

    3.79 miles

  • 70th Street

    5.19 miles

  • Morena/Linda Vista

    5.55 miles

  • Old Town Transit Center

    6.07 miles

  • Arco

    0.11 miles

  • 7-Eleven

    0.23 miles

  • Tierrasanta Town Center Gas and Carwash

    1.35 miles

  • 76

    1.43 miles

  • mobil

    1.63 miles

  • Tesla Supercharger

    1.66 miles

  • USA Gasoline

    1.84 miles

  • EBK Fuel

    1.88 miles

  • Chevron

    1.92 miles

  • San Diego - Clairemont Mesa Boulevard Supercharger

    2.79 miles

  • Farnham Parking Structure

    1.72 miles

  • Chesapeake Parking Structure

    1.95 miles

  • Kaiser Permanente Parking Garage

    1.96 miles

  • Childrens Hospital Park And Ride

    1.98 miles

  • Rady's Childrens Hospital Park And Ride

    2.11 miles

  • Sharp Birmingham Parking Garage

    2.15 miles

  • HealthCenter Drive Parking Structure

    2.30 miles

  • Foster Elementary School Parking Lot

    2.39 miles

  • Lot 2

    2.59 miles

  • Lot 4

    2.59 miles

  • Hilton Garden Inn

    0.22 miles

  • TownePlace Suites San Diego Central

    1.53 miles

  • Four Points by Sheraton San Diego

    1.73 miles

  • Courtyard San Diego Central

    1.75 miles

  • Synergy at Mira Bella

    1.78 miles

  • Pidgeon at Monte Viston

    1.82 miles

  • Ronald McDonald House

    2.03 miles

  • Ramada San Diego North Hotel & Conference Center;Ramada San Diego North Hotel and Conference Center

    2.16 miles

  • Residence Inn San Diego Central

    2.18 miles

  • Hampton Inn San Diego - Kearny Mesa

    2.19 miles

  • Vons

    0.24 miles

  • Walmart

    0.38 miles

  • Smart & Final

    1.29 miles

  • Marukai Food

    1.85 miles

  • Hawthorne Crossings

    1.88 miles

  • Ross

    1.89 miles

  • Target

    1.91 miles

  • Mitsuwa Marketplace

    1.92 miles

  • Nijiya Market

    2.06 miles

  • Primo Market

    2.33 miles

3645 Ruffin Rd. Listing Brief

  • Leasing rates here can depend on a variety of factors, including the quality rating of the property (property class or building class), the position of the available space within the building, any unique attributes that the listed space may include, as well as on the availability of on-site or nearby amenities. Reach out using the contact form available on this page to schedule a tour or to get more detailed information on the most modern facilities and amenities that 3645 Ruffin Rd. has to offer.

  • See the listing area details for information and ratings regarding the degree of walkability in the neighborhood, the accessibility and frequency of public transit options, as well as the level of availability and quality of biking infrastructure in the area. What’s more, you can use the interactive map for a good overview of the area. Location details also include a breakdown of distance from the property to several essential amenities and points of interest, which may include parking facilities, fuel stations, stores, or hotels.

  • This property is in the Kearny Mesa neighborhood of San Diego and located within zip code 92123.

    3645 Ruffin Rd. is rated class B. The building includes 40,000 square feet, of which 3,127 square feet is rentable office space.

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