Map of Property

5406 US-280

For Lease

5406 US-280, Birmingham, AL 35242

You can currently find 5 retail space(s) available for lease at 5406 US-280. Designated use type for space listed here includes retail. Current retail listings at this property total 13,345 square feet. Lease type options include NNN. Expand the listing and property details below for additional information on leasing opportunities at 5406 US-280.

Space Available For Lease 5

Contacts

Katy Lincoln

Lincoln Holdings

Property Details

  • Property Type Retail
  • Property Size 13,345 SF
  • Date Updated Jun 26, 2026

Join Andrews Sports Medicine, Skin Wellness Dermatology, ENT for Kids, and Birmingham Orthodontics, in this premier medical location on Highway 280.

 

The Crossroads at Greystone offers a convenient, neighborhood center setting for your next location. Building signage and ample parking in a drive-up setting provides an easy experience for patients and visitors.

 

Multiple suite sizes are available and build out packages can be customized to your exact layout needs.

 

85,500 vehicles per day on Highway 280

 

18,800 vehicles per day on Highway 119 (Cahaba Valley Road)

 

Excellent signage (building and monument)

 

Drive up parking for a convenient patient experience

 

Multiple ingress/egress points and traffic light access to Highway 280

 

Convenient to Birmingham’s major neighborhoods: Inverness, Meadowbrook, Greystone and continued growth down Highway 280 

Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

Getting around

  • 54/100

    Walk Score ®

  • 39/100

    Bike Score ®

Powered by Walk Score ®

Location

  • City Birmingham, AL
  • Neighborhood Greystone
  • Zip Code 35242
  • Market Birmingham

Points of Interest

  • Shell

    0.08 miles

  • Cowboys

    0.74 miles

  • BP

    1.61 miles

  • Chevron

    1.77 miles

  • 1314- Dunnavant Valley Chevron

    2.43 miles

  • Tesla Supercharger

    2.48 miles

  • ChargePoint

    7.39 miles

  • Mountain Brook, AL Supercharger

    7.58 miles

  • Leeds, AL Supercharger

    9.99 miles

  • Grandview Emergency Parking

    2.83 miles

  • Grandview Parking Deck

    2.94 miles

  • Parking Deck

    3.23 miles

  • North Trailhead Parking

    4.55 miles

  • School bus parking lot

    7.03 miles

  • Pizitz Parking lot

    7.13 miles

  • Track and Soccer Stadium Parking

    7.68 miles

  • The Fish Market Restaurant

    0.18 miles

  • Chick-fil-A

    0.20 miles

  • Krispy Kreme

    0.25 miles

  • Jim 'N Nick's

    0.34 miles

  • Waffle House

    0.36 miles

  • Walk-On's

    0.42 miles

  • Moe's Southwest Grill

    0.48 miles

  • Five Guys

    0.49 miles

  • Taco Bell

    0.49 miles

  • DQ Grill & Chill

    0.50 miles

  • Publix

    0.28 miles

  • Walmart Supercenter

    0.41 miles

  • Sprouts Farmers Market

    0.73 miles

  • TJ Maxx

    1.26 miles

  • Winn-Dixie

    1.35 miles

  • Kohl's

    1.47 miles

  • The Fresh Market

    1.69 miles

  • ALDI

    1.93 miles

  • Piggly Wiggly

    2.39 miles

  • Target

    2.47 miles

5406 US-280 Listing Brief

  • A property’s location contributes to the asking rent almost as much as its characteristics do. For instance, central urban locations with high walkability or suburban locations with ample parking and easy access by car will claim higher rents but offer superior access to your customer base. Likewise, the quality of the building systems and property finishes have a significant impact on how businesses can conduct their activity there, as well as on the experience of their customers.

    5406 US-280 is located in Greystone, which is home to a total of 12 listing(s). Retail space at 5406 US-280 asks $24.00/SF/YR per square foot.

  • The property includes 13,345 square feet of retail space for lease. Of this total, 13,345 square feet are Retail.

    Lease agreement conditions for the availability at this property include NNN.

    For more information or to schedule a tour of the property, use the convenient contact form on this page to get in touch with a representative.

  • You should keep in mind that different areas gradually build a reputation as hotspots or desirable corridors for shopping, eating, or other entertainment and consumer activities. So, while renting retail space in an area with a well-established high-end reputation might mean more customers that are more willing to spend, it will also place you in a more competitive environment.

    Knowing your ideal customer is essential. For your consideration, the average age of residents in Greystone is 44. The average household income here is $117,047 per year.

Contact Listing Broker
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