{"id":1004785635,"date":"2026-01-29T05:03:09","date_gmt":"2026-01-29T13:03:09","guid":{"rendered":"https:\/\/www.commercialsearch.com\/news\/?p=1004785635"},"modified":"2026-01-29T05:03:11","modified_gmt":"2026-01-29T13:03:11","slug":"biotechnology-firm-to-relocate-hq-in-boston","status":"publish","type":"post","link":"https:\/\/www.commercialsearch.com\/news\/biotechnology-firm-to-relocate-hq-in-boston\/","title":{"rendered":"Biotechnology Firm to Relocate HQ in Boston"},"content":{"rendered":"\n<p><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a3abc21d7be1&quot;}\" data-wp-interactive=\"core\/image\" class=\"alignright size-full is-resized wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"750\" data-attachment-id=\"1004785683\" data-permalink=\"https:\/\/www.commercialsearch.com\/news\/biotechnology-firm-to-relocate-hq-in-boston\/245-fifth-ave-3\/\" data-orig-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2026\/01\/245-Fifth-Ave.jpg\" data-orig-size=\"1000,750\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"245 Fifth Ave.\" data-image-description=\"&lt;p&gt;https:\/\/www.citybiz.co\/article\/799105\/anchor-line-partners-supports-stoke-therapeutics-growth-by-securing-a-98500-square-foot-lease-in-waltham-ma\/&lt;\/p&gt;\n\" data-image-caption=\"&lt;p&gt;The six-story building came online last year. Image courtesy of Anchor Line Partners and Northwood Investors&lt;\/p&gt;\n\" data-large-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2026\/01\/245-Fifth-Ave.jpg?w=1000\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on-async--click=\"actions.showLightbox\" data-wp-on-async--load=\"callbacks.setButtonStyles\" data-wp-on-async-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2026\/01\/245-Fifth-Ave.jpg\" alt=\"Exterior shot of 245 Fifth Ave., an office building in Waltham, Mass.\" class=\"wp-image-1004785683\" style=\"width:400px\" srcset=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2026\/01\/245-Fifth-Ave.jpg 1000w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2026\/01\/245-Fifth-Ave.jpg?resize=300,225 300w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2026\/01\/245-Fifth-Ave.jpg?resize=768,576 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on-async--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">The six-story building came online last year. <em>Image courtesy of Anchor Line Partners and Northwood Investors<\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Stoke Therapeutics has signed a 98,500-square-foot headquarters lease at 245 Fifth Ave., a 262,000-square-foot office building in Waltham, Mass., near Boston. Anchor Line Partners and Northwood Investors own the six-story building.<\/p>\n\n\n\n<p>Cushman &amp; Wakefield arranged the long-term agreement. The brokerage company also handles leasing efforts.<\/p>\n\n\n\n<p>This <a href=\"https:\/\/www.commercialsearch.com\/news\/where-are-most-corporate-relocations-taking-place\/\">corporate relocation<\/a> will involve the biotechnology firm moving out by the end of this year from its current lease, which is at a 36,800-square-foot office building in Bedford, Mass., Yardi Matrix shows. Stoke is focused on restoring protein expression through RNA medicine and is developing its lead investigational therapy.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity has-very-light-gray-to-cyan-bluish-gray-gradient-background has-background is-style-wide\"\/>\n\n\n\n<p><strong>READ ALSO: <\/strong><a href=\"https:\/\/www.commercialsearch.com\/news\/where-opportunity-lies-in-2026\/\">Where Opportunity Lies in 2026<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity has-very-light-gray-to-cyan-bluish-gray-gradient-background has-background is-style-wide\"\/>\n\n\n\n<p>The LEED Gold-certified building is close to Interstate 95 and less than 3 miles from Waltham\u2019s city center. Downtown Boston is within 18 miles, while Boston Logan International Airport is 20 miles southeast.<\/p>\n\n\n\n<p>Completed last year, the mid-rise has floorplates averaging 50,000 square feet and is part of a six-building campus within the CityPoint neighborhood. The complex totals 783,000 square feet.<\/p>\n\n\n\n<p>The property also has 18,000 square feet of amenities, which include a coworking lounge, fitness center, library, game room, food truck hall and meditation rooms, as well as outdoor flex space.<\/p>\n\n\n\n<p>Cushman &amp; Wakefield Senior Director Mitch Perez, Executive Vice Chair Connor Barnes and Executive Director Michael Weiss represented Stoke in the deal. Executive Managing Directors Michael O\u2019Leary and Duncan Gratton handle leasing efforts at 245 Fifth Ave.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-boston-s-office-vacancy-sees-year-over-year-decline\">Boston\u2019s office vacancy sees year-over-year decline<\/h2>\n\n\n\n<p>Boston\u2019s office vacancy rate at the end of November clocked in at 15.4 percent, dropping 140 basis points year-over-year, according to a <a href=\"https:\/\/www.commercialsearch.com\/news\/office-report-construction-falls-to-historic-lows-pricing-reached-bottom\/\">Yardi Matrix office report<\/a>. The metro\u2019s average listing rates as of the same month reached $48.66, increasing 3 percent compared to a year prior.<\/p>\n\n\n\n<p>In November, <a href=\"https:\/\/www.commercialsearch.com\/news\/state-street-takes-162-ksf-near-boston\/\">State Street signed<\/a> a 162,000-square-foot commitment at 700 District Ave. in Burlington, Mass. The deal represents the renewal of 147,000 square feet of space, along with a 15,000-square-foot expansion.<\/p>\n\n\n\n<p>Leasing activity remained active at the beginning of this year as well. Last week, <a href=\"https:\/\/www.commercialsearch.com\/news\/biopharma-firm-triples-space-at-boston-campus\/\">Roche expanded its presence<\/a> at One Milestone in the Innovation Center at the Harvard Enterprise Research Campus to 100,000 square feet, up from its initial 30,000-square-foot commitment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The firm will occupy 98,500 square feet starting this year.<\/p>\n","protected":false},"author":3355,"featured_media":1004785683,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1490,21784,21742,10,21747],"tags":[32799,34258],"class_list":["post-1004785635","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-boston","category-brokerage","category-latest","category-northeast","category-office","tag-cushman-wakefield","tag-northwood-investors"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.4 (Yoast SEO v24.6) - 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