{"id":1004756040,"date":"2025-05-01T07:18:22","date_gmt":"2025-05-01T15:18:22","guid":{"rendered":"https:\/\/www.commercialsearch.com\/news\/?p=1004756040"},"modified":"2025-05-06T01:06:47","modified_gmt":"2025-05-06T09:06:47","slug":"life-science-developments-guarded-prognosis","status":"publish","type":"post","link":"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/","title":{"rendered":"Life Science Development&#8217;s Guarded Prognosis"},"content":{"rendered":"\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a3b64bec8f66&quot;}\" data-wp-interactive=\"core\/image\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1004756054\" data-permalink=\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/healthcare-medical-stethoscope-confusion-tangled-concept\/\" data-orig-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/iStock-1277412632-Illustration-by-Filo.jpg\" data-orig-size=\"1200,900\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Brandon Laufenberg&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;Healthcare and medicine tangled complex confusion medical illustration concept.&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;\\u00a9Brandon Laufenberg 2020. All rights reserved.&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;Healthcare Medical Stethoscope Confusion Tangled Concept&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"iStock-1277412632 Illustration by Filo\" data-image-description=\"&lt;p&gt;Illustration by Filo\/iStockphoto.com&lt;\/p&gt;\n\" data-image-caption=\"&lt;p&gt;Life Science. Illustration by Filo\/iStockphoto.com&lt;\/p&gt;\n\" data-large-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/iStock-1277412632-Illustration-by-Filo.jpg?w=1024\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on-async--click=\"actions.showLightbox\" data-wp-on-async--load=\"callbacks.setButtonStyles\" data-wp-on-async-window--resize=\"callbacks.setButtonStyles\" height=\"768\" width=\"1024\" src=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/iStock-1277412632-Illustration-by-Filo.jpg?w=1024\" alt=\"Healthcare and medicine tangled complex confusion medical illustration concept.\" class=\"wp-image-1004756054\" srcset=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/iStock-1277412632-Illustration-by-Filo.jpg 1200w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/iStock-1277412632-Illustration-by-Filo.jpg?resize=300,225 300w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/iStock-1277412632-Illustration-by-Filo.jpg?resize=768,576 768w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/iStock-1277412632-Illustration-by-Filo.jpg?resize=1024,768 1024w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on-async--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\"><em>Illustration by Filo\/iStockphoto.com<\/em><\/figcaption><\/figure>\n\n\n\n<p class=\"has-drop-cap\">As of early spring, thousands of jobs had been eliminated at several major health agencies.&nbsp;How much these cuts will affect drug development, and ultimately the demand for space, remains to be seen.<\/p>\n\n\n\n<p>Perhaps more consequential in the short term, the quantity of space delivered in the major life sciences markets across the country from 2019 to 2021 substantially outpaced demand, reported Joseph Fetterman, an executive vice president at Colliers. \u201cWithout a dramatic increase in funding for promising drug development activity, it could take three to six years to absorb the existing surplus in many markets,\u201d he said.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-fl-body-text-color has-text-color has-background wp-element-button\" href=\"https:\/\/mydigitalpublication.com\/publication\/?i=845591\" style=\"background-color:#1bb1ae\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>READ THE MAGAZINE<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Signs of softening characterize the<a href=\"https:\/\/www.commercialsearch.com\/news\/life-science-market-finds-its-spark\/\"> life science market\u2019s fundamentals<\/a>. Net absorption was negative again in 2024, as the nationwide vacancy rate ticked up 250 basis points to 20.5 percent from the second quarter to the end of the year, according to Cushman &amp; Wakefield\u2019s recent life science update.<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a3b64becac33&quot;}\" data-wp-interactive=\"core\/image\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1004756048\" data-permalink=\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/softening-demand\/\" data-orig-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/Softening-Demand.jpg\" data-orig-size=\"1119,418\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Softening Demand\" data-image-description=\"&lt;p&gt;Softening demand&lt;br \/&gt;\nLife science construction activity as a percentage of total inventory&lt;\/p&gt;\n\" data-image-caption=\"&lt;p&gt;Source: Cushman &#038; Wakefield Life Sciences Update, March 2025&lt;\/p&gt;\n\" data-large-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/Softening-Demand.jpg?w=1024\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on-async--click=\"actions.showLightbox\" data-wp-on-async--load=\"callbacks.setButtonStyles\" data-wp-on-async-window--resize=\"callbacks.setButtonStyles\" height=\"383\" width=\"1024\" src=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/Softening-Demand.jpg?w=1024\" alt=\"Softening demand\nLife science construction activity as a percentage of total inventory\" class=\"wp-image-1004756048\" srcset=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/Softening-Demand.jpg 1119w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/Softening-Demand.jpg?resize=300,112 300w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/Softening-Demand.jpg?resize=768,287 768w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/Softening-Demand.jpg?resize=1024,383 1024w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on-async--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Source: Cushman &amp; Wakefield Life Sciences Update, March 2025<\/figcaption><\/figure>\n\n\n\n<p>Development is slowing, as well. Although 16 million square feet were under construction at the end of 2024, only 2 million square feet are in the pipeline. Rent growth was mixed, as Chicago, Denver and the Los Angeles-Orange County region gained, while the growth rate slowed by double digits in Boston and New York City.<\/p>\n\n\n\n<p>The nationwide vacancy for lab space is about 26 percent, reporter Kevin Wayer, president of JLL\u2019s global life sciences division. While aiming to stay cautiously optimistic, he observed that \u201cthere\u2019s a fair amount of space to work through.\u201d Last year the top 25 life science-focused venture capital firms raised about $15 billion, added Wayer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-venture-capital-still-a-fan\">Venture capital: Still a fan<\/h2>\n\n\n\n<p>One encouraging trend that may point to long-term demand for new life science product is continued strong interest from venture capital. Reversing a two-year slide, last year life sciences firms raised $26 billion, up from $23.3 billion in 2023, according to JP Morgan\u2019s annual report. As BioMed Realty CEO Timothy Schoen noted, that surpassed both pre-COVID and long-term averages.<\/p>\n\n\n\n<p>Fundraising increased year-over-year in each quarter, and 98 companies raised rounds of $100 million, beating the total for each of the previous two years. This year, venture capital activity (will be) focused on mega-rounds\u2014$100 million-plus investments in companies with proven product data, predicted Ryan Shannon, executive vice president of finance at IQHQ.<\/p>\n\n\n\n<p>Biotech and pharmaceutical companies are also funding growth through a variety of other approaches, including IPO activity, M&amp;A, private investment in public equity deals, and VC raises at later-stage private companies. \u201cThese companies are accelerating their growth objectives in order to backfill revenues from near-term patent expirations while also seeking new value-creating investments,\u201d said IQHQ Co-CEO Tracy Murphy.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a3b64becbac5&quot;}\" data-wp-interactive=\"core\/image\" class=\"alignright size-large is-resized wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1004756046\" data-permalink=\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/gilbane-building-company-usq-2\/\" data-orig-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/10ProspectSt_elevated_CreditGilbaneBuilding.jpg\" data-orig-size=\"1200,900\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Gilbane Building Company&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;USQ&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;Gilbane Building Company-USQ&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"Gilbane Building Company-USQ\" data-image-description=\"&lt;p&gt;Next door to Cambridge\u2019s life science hub, Somerville, Mass., is benefiting from its location next door to Cambridge with such projects as 10 &lt;\/p&gt;\n\" data-image-caption=\"&lt;p&gt;Next door to Cambridge\u2019s life science hub, Somerville, Mass., is benefiting from its location next door to Cambridge with such projects as 10 Prospect Street, completed in 2023. Image courtesy of Gilbane Building Co. &lt;\/p&gt;\n\" data-large-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/10ProspectSt_elevated_CreditGilbaneBuilding.jpg?w=1024\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on-async--click=\"actions.showLightbox\" data-wp-on-async--load=\"callbacks.setButtonStyles\" data-wp-on-async-window--resize=\"callbacks.setButtonStyles\" height=\"768\" width=\"1024\" src=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/10ProspectSt_elevated_CreditGilbaneBuilding.jpg?w=1024\" alt=\"Mid-rise charcoal-gray office building with two setback levels at the top\" class=\"wp-image-1004756046\" style=\"width:400px\" srcset=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/10ProspectSt_elevated_CreditGilbaneBuilding.jpg 1200w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/10ProspectSt_elevated_CreditGilbaneBuilding.jpg?resize=300,225 300w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/10ProspectSt_elevated_CreditGilbaneBuilding.jpg?resize=768,576 768w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/10ProspectSt_elevated_CreditGilbaneBuilding.jpg?resize=1024,768 1024w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on-async--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Next door to Cambridge\u2019s life science hub, Somerville, Mass., is benefiting from its location next door to Cambridge with such projects as 10 Prospect Street, completed in 2023. Image courtesy of Gilbane Building Co. <\/figcaption><\/figure><\/div>\n\n\n<p class=\"has-background\" style=\"background-color:#ffe484\"><strong>Beyond the big three: emerging hubs<\/strong><br><strong><br><\/strong>Though life science real estate continues to be dominated by the big three\u2014the San Francisco Bay region, San Diego and the Boston\u2013Cambridge hub\u2014there is no shortage of activity in other markets. An attractive location and a vibrant university presence help create the conditions for a plethora of mini-hubs across the country. According to an analysis by Pitchbook, six markets attracted at least $75 million in public and private life science investment last year: Austin, Indianapolis, Houston, Phoenix, Dallas\u2013Fort Worth and Salt Lake City.<br><br>The locations named by life science real estate experts indicate the remarkable diversity of these niche markets. Timothy Schoen, CEO of BioMed Realty, cites Boulder, Colo., home of a University of Colorado campus. Pittsburgh, Minneapolis, Salt Lake City, St. Louis and New Haven, Conn., all get a thumbs-up from Joseph Fetterman, an executive vice president at Colliers. For Jeffrey Myers, a Boston-based research director for Colliers, at least three Sun Belt markets make the grade: Houston, Nashville and Birmingham, Ala.<br><br>New mini-hubs are springing up next door to the big three, as well. Somerville, Mass., a Cambridge neighbor, had no purpose-built lab space before the pandemic, but today boasts more than 2 million square feet.<br><br>\u201cWhen the market was white-hot, developers were able to spread out from traditional nodes, and tenants were forced to follow,\u201d Fetterman said. \u201cSomerville benefitted from this trend and its proximity to well-established clusters in Cambridge.\u201d A high-profile example is 10 Prospect St., completed in 2023 by a joint venture of Magellan Development Group,&nbsp;RAS Development,&nbsp;Cypress Equity Investments&nbsp;and&nbsp;Affinius Capital. The 205,000-square-foot building is a part of the venture\u2019s $2 billion, 1.5 million-square-foot USQ project.<br><br>In Philadelphia, the Station District is emerging around Amtrak\u2019s 30th Street Station as a mini-hub in the University City submarket. As Fetterman notes, the neighborhood has been gaining momentum since Brandywine converted the former Bulletin Building to a 50,000-square-foot R&amp;D headquarters for Roche\u2019s Spark Therapeutics.<br><br>At Cira Centre, the 29-story trophy tower adjacent to 30th Street Station, Brandywine converted multiple floors to lab space and launched an incubator. All told, the Station District now has 1.15 million square feet of purpose-built development scheduled to deliver in the first half of this year, including a new 500,000-square-foot Spark\/Roche manufacturing facility, and 50,000 square feet of space conversion in the works, as well as a proposed 185,000-square-foot purpose-built lab project.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-quest-for-construction-capital\">Quest for construction capital<\/h2>\n\n\n\n<p>Construction financing paints a tighter picture. The bar for securing life science financing is very high in today\u2019s environment, noted Wayer, \u201cbut for the right projects, capital is still available.&#8221;&nbsp;Those projects are typically characterized by diversified rent rolls or investment-grade tenants.<\/p>\n\n\n\n<p>He noted that the biggest players of pharma, biotech and medtech have less need for outside capital, as they can use cash proceeds from operations and M&amp;A for manufacturing, lab or office space. Otherwise, construction financing can be extremely challenging, though public capital participation can help solve some of the gap financing needs. \u201cYou\u2019ll start to see some creativity around that,\u201d he predicted.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a3b64beccd10&quot;}\" data-wp-interactive=\"core\/image\" class=\"alignright size-large is-resized wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1004756057\" data-permalink=\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/75broadway_creditbiomedrealty\/\" data-orig-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/75Broadway_CreditBioMedRealty.jpg\" data-orig-size=\"1900,2000\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"75Broadway_CreditBioMedRealty\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;Biogen signed a 15-year lease with a joint venture of MIT Investment Management Co. and BioMed Realty for a 580,000-square-foot headquarters building at 75 Broadway in the Kendall Square area of Cambridge, Mass. Scheduled to open in 2028, the facility will create an innovation hub that brings together the company\u2019s R&#038;D, technical operations and commercial units.  Image courtesy of BioMed&lt;\/p&gt;\n\" data-large-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/75Broadway_CreditBioMedRealty.jpg?w=973\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on-async--click=\"actions.showLightbox\" data-wp-on-async--load=\"callbacks.setButtonStyles\" data-wp-on-async-window--resize=\"callbacks.setButtonStyles\" height=\"1024\" width=\"973\" src=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/75Broadway_CreditBioMedRealty.jpg?w=973\" alt=\"rendering of a curvilinear glass-and-steel high-rise building with horizontal aqua bands at each floor, with older brick buildings in the foreground and pale skyscrapers in the background\" class=\"wp-image-1004756057\" style=\"width:500px\" srcset=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/75Broadway_CreditBioMedRealty.jpg 1900w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/75Broadway_CreditBioMedRealty.jpg?resize=285,300 285w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/75Broadway_CreditBioMedRealty.jpg?resize=768,808 768w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/75Broadway_CreditBioMedRealty.jpg?resize=973,1024 973w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/75Broadway_CreditBioMedRealty.jpg?resize=1459,1536 1459w\" sizes=\"auto, (max-width: 973px) 100vw, 973px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on-async--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Biogen signed a 15-year lease with a joint venture of MIT Investment Management Co. and BioMed Realty for a 580,000-square-foot headquarters building at 75 Broadway in the Kendall Square area of Cambridge, Mass. Scheduled to open in 2028, the facility will create an innovation hub that brings together the company\u2019s R&amp;D, technical operations and commercial units. <em> Image courtesy of BioMed<\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Another key factor in new development at a time of surplus space\u2014landing an anchor tenant. That\u2019s what led to a major project in Kendall Square, the life science cluster near the Massachusetts Institute of Technology in Cambridge, Mass. In March, Biogen signed a 15-year lease with a joint venture of MIT Investment Management Co. and BioMed Realty for a 580,000-square-foot headquarters building at 75 Broadway, which is scheduled to open in 2028. That project will follow the debut of another major Kendall Square development: BioMed\u2019s 585 Kendall, a 637,000-square-foot building anchored by Takeda Pharmaceuticals and scheduled for a 2026 opening.<\/p>\n\n\n\n<p>\u201cGiven the record-high vacancy rate in the submarket, without a tenant in hand, the developer of this project would not likely have been able to move forward,\u201d said Jeffrey Myers, a research director with Colliers. \u201cVery few lab buildings are breaking ground these days, and those that do typically involve projects with anchor tenants and strong sponsors.\u201d<\/p>\n\n\n\n<p>The most active lenders for <a href=\"https:\/\/www.commercialsearch.com\/news\/the-most-active-life-sciences-markets-in-the-us\/\">life science development <\/a>include national and major regional banks, debt funds (such as Square Mile Capital and Blackstone Real Estate Debt Strategies) and life science-focused investors such as Alexandria and King Street, which provide debt as well as equity.<\/p>\n\n\n\n<p>\u201cWith a preference for Tier 1 life sciences clusters, construction debt is 150-250 basis points higher than a year ago,\u201d said Fetterman. \u201cIn addition, leverage has compressed with loan-to-cost levels at 60 percent or below.\u201d Rising construction costs are pushing lenders to underwrite construction deals with 10 to 15 percent contingency, he added.<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a3b64becdc67&quot;}\" data-wp-interactive=\"core\/image\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1004756050\" data-permalink=\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/new-construction-leasing-in-top-markets\/\" data-orig-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/New-construction-leasing-in-top-markets.jpg\" data-orig-size=\"1152,297\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"New construction leasing in top markets\" data-image-description=\"&lt;p&gt;New construction leasing in top markets&lt;br \/&gt;\nPreleased and available space for projects scheduled for 2025 completion, in million square feet&lt;\/p&gt;\n\" data-image-caption=\"&lt;p&gt;Source: Cushman &#038; Wakefield Life Sciences Update, March 2025&lt;\/p&gt;\n\" data-large-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/New-construction-leasing-in-top-markets.jpg?w=1024\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on-async--click=\"actions.showLightbox\" data-wp-on-async--load=\"callbacks.setButtonStyles\" data-wp-on-async-window--resize=\"callbacks.setButtonStyles\" height=\"264\" width=\"1024\" src=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/New-construction-leasing-in-top-markets.jpg?w=1024\" alt=\"New construction leasing in top markets\nPreleased and available space for projects scheduled for 2025 completion, in million square feet\n\" class=\"wp-image-1004756050\" srcset=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/New-construction-leasing-in-top-markets.jpg 1152w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/New-construction-leasing-in-top-markets.jpg?resize=300,77 300w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/New-construction-leasing-in-top-markets.jpg?resize=768,198 768w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/New-construction-leasing-in-top-markets.jpg?resize=1024,264 1024w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on-async--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Source: Cushman &amp; Wakefield Life Sciences Update, March 2025<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-why-bigger-is-better\">Why bigger is better<\/h2>\n\n\n\n<p>When it comes to project size, large life sciences campuses can provide significant advantages, according to executives. Locations offering plenty of room for collaboration, retail options, amenities and access to transportation will continue to dominate the sector, said Murphy\u2019s IQHQ. She cites the firm\u2019s 2024 delivery of three projects comprising 1.9 million square feet of new construction and the expected debut this year of 1.4 million square feet in the core markets of San Diego, the San Francisco Bay region and Boston.<\/p>\n\n\n\n<p>In February, IQHQ secured a landmark lease at Elco Yards, its 670,000-square-foot mixed-use development in Redwood City, Calif. The Chan Zuckerberg Initiative committed to 225,000 square feet for biomedical research and AI-driven science initiatives and will occupy its new space in 2027, Murphy said.<br>Although big campuses have historically been the domain of big pharma, over time this tranche has been shedding older R&amp;D and manufacturing sites. \u201cDevelopers have acquired these campuses as suburban life science campuses, leasing portions of the park and redeveloping less marketable, underdeveloped or undeveloped parts of the campus,\u201d added Fetterman.<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a3b64beceb00&quot;}\" data-wp-interactive=\"core\/image\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"1004756060\" data-permalink=\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/elcoyards_photojeffdurkin_courtesyiqhq\/\" data-orig-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/ElcoYards_photoJeffDurkin_courtesyIQHQ.png\" data-orig-size=\"1200,900\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"ElcoYards_photoJeffDurkin_courtesyIQHQ\" data-image-description=\"&lt;p&gt;aerial view of a construction site with multiple low-rise buildings and a tower crane in the center&lt;\/p&gt;\n\" data-image-caption=\"&lt;p&gt;The Chan Zuckerberg Initiative recently committed to a 225,000-square-foot lease at Elco Yards, IQHQ\u2019s mixed-use campus in Redwood, Calif. One of four planned buildings at the cite, CZI\u2019s facility will house biomedical research and AI-driven science initiatives. The 670,000-square-foot campus will include lab, office and retail space. Photo by Jeff Durkin, courtesy of IQHQ &lt;\/p&gt;\n\" data-large-file=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/ElcoYards_photoJeffDurkin_courtesyIQHQ.png?w=1024\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on-async--click=\"actions.showLightbox\" data-wp-on-async--load=\"callbacks.setButtonStyles\" data-wp-on-async-window--resize=\"callbacks.setButtonStyles\" height=\"768\" width=\"1024\" src=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/ElcoYards_photoJeffDurkin_courtesyIQHQ.png?w=1024\" alt=\"aerial view of a construction site with multiple low-rise buildings and a tower crane in the center\" class=\"wp-image-1004756060\" srcset=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/ElcoYards_photoJeffDurkin_courtesyIQHQ.png 1200w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/ElcoYards_photoJeffDurkin_courtesyIQHQ.png?resize=300,225 300w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/ElcoYards_photoJeffDurkin_courtesyIQHQ.png?resize=768,576 768w, https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/ElcoYards_photoJeffDurkin_courtesyIQHQ.png?resize=1024,768 1024w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on-async--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">The Chan Zuckerberg Initiative recently committed to a 225,000-square-foot lease at Elco Yards, IQHQ\u2019s mixed-use campus in Redwood, Calif. One of four planned buildings at the cite, CZI\u2019s facility will house biomedical research and AI-driven science initiatives. The 670,000-square-foot campus will include lab, office and retail space. <em>Photo by Jeff Durkin, courtesy of IQHQ <\/em><\/figcaption><\/figure>\n\n\n\n<p>He expects almost all new development in the near future to be individual build-to-suit buildings or projects, led by an anchor tenant with a specific need that can\u2019t be satisfied by existing inventory. \u201cWith the inventory of purpose-built R&amp;D buildings, it is likely that in the near term we will see more redevelopment or new development for specialized (Current Good Manufacturing Practice) requirements.\u201d<\/p>\n\n\n\n<p>Life sciences campuses are a key solution not only for larger firms but also for smaller firms, which can benefit from participating in an ecosystem of companies, people and ideas, executives say. \u201cUnlike other industries where companies can operate remotely, life sciences rely heavily on in-person collaboration\u2014lab work simply can\u2019t happen over Zoom,\u201d commented Sonia Taneja, west region market leader &amp; managing director at King Street Properties. \u201cThis commitment to physical spaces has kept demand in established life science clusters.\u201d<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center has-background\" style=\"background-color:#16a19a33\"><em><a href=\"https:\/\/mydigitalpublication.com\/publication\/?i=845591\">Read the May 2025 issue of CPE.<\/a><\/em><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Is there a cure for the post-pandemic lull? <\/p>\n","protected":false},"author":882,"featured_media":1004756054,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[21782,1521,21808,51037],"tags":[],"class_list":["post-1004756040","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-development","category-digital","category-featured","category-trends"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.4 (Yoast SEO v24.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Life Science Development&#039;s Guarded Prognosis - Commercial Property Executive<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Life Science Development&#039;s Guarded Prognosis\" \/>\n<meta property=\"og:description\" content=\"Is there a cure for the post-pandemic lull?\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Commercial Property Executive\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CPExecutive\" \/>\n<meta property=\"article:published_time\" content=\"2025-05-01T15:18:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-06T09:06:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/iStock-1277412632-Illustration-by-Filo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Scott Baltic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@cpexecutive\" \/>\n<meta name=\"twitter:site\" content=\"@cpexecutive\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/\",\"url\":\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/\",\"name\":\"Life Science Development's Guarded Prognosis - Commercial Property Executive\",\"isPartOf\":{\"@id\":\"https:\/\/www.commercialsearch.com\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/iStock-1277412632-Illustration-by-Filo.jpg\",\"datePublished\":\"2025-05-01T15:18:22+00:00\",\"dateModified\":\"2025-05-06T09:06:47+00:00\",\"author\":{\"@id\":\"https:\/\/www.commercialsearch.com\/news\/#\/schema\/person\/61ac1450f3ffaa0e850b834c28526555\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.commercialsearch.com\/news\/life-science-developments-guarded-prognosis\/#primaryimage\",\"url\":\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/iStock-1277412632-Illustration-by-Filo.jpg\",\"contentUrl\":\"https:\/\/www.commercialsearch.com\/news\/wp-content\/uploads\/sites\/46\/2025\/04\/iStock-1277412632-Illustration-by-Filo.jpg\",\"width\":1200,\"height\":900,\"caption\":\"Life Science. 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He started writing about CRE in 1988 for a group of Chicago-based publications and in 1989 became the editor of Midwest Real Estate News. After moving on from there in 1991, Baltic continued writing occasionally about real estate, for publications like the Chicago Sun-Times, National Real Estate Investor, Urban Land, Shopping Center World and Architect\u2019s Newspaper. 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